糖尿病肾病动物模型的研究进展

糖尿病肾病是终末期肾衰的主要原因,也是糖尿病致命的重要原因。但是糖尿病肾病的致病机制迄今尚不完全明了,理想的动物模型无疑可对糖尿病肾病的研究提供重要线索。糖尿病肾病动物模型包括诱发性、自发性和转基因等多种类型的动物模型,各种类型的动物模型在疾病的发生发展、病理生理变化等多个方面与人类糖尿病肾病具有相似的特征。应用这些模型有助于开展对糖尿病肾病的防治、发病机理、相关药物的开发等多方面的研究。

Recent Advances in Research on Animal Models of Diabetic Nephropathy

Diabetic nephropathy(DN) represents the most frequent cause of end-stage renal disease(ESRD) and threatens the life of patients with diabetes mellitus(DM).However,the pathomechanisms which cause renal damage in diabetes have not been completely clarified.An appropriate animal model may provide an opportunity for investigation of diabetic nephropathy.The animal models of diabetic nephropathy include induced,spontaneous and transgenic rodent or non-rodent.Some of the characteristics of these animal models are similar to those of human diabetic nephropathy in the development,pathogenesis,and functional and structural lesions of renal disease.The animal models of diabetic nephropathy can be applied in research of preventive medicine,etiology and mechanism of human diabetic nephropathy,and also to explore new medicines and therapeutic strategies to prevent progressive renal disease in diabetes.