32例口腔粘膜黑色素瘤病理与免疫组织化学研究

对３２例口腔粘膜原发恶性黑色素瘤进行临床病理学及免疫组织化学观察。结果显示：本组病例无明显性别差异，平均年龄４１．６岁，其中４０岁以上２３例（７１．９％）。病变发生上腭１３例（４０．６％），牙龈及牙槽粘膜１２例（３７．５％），其它部位少见。以黑色肿块为突出的临床表现，其次为区域淋巴结肿大与病变周围粘膜存在黑色斑块。镜下见，肿瘤细胞成分多样，组织结构复杂多变。肿瘤细胞几乎不同程度的表达Ｓ－１００蛋白和波形蛋白。多种抗体联用，对提高诊断的准确性有帮助。

Primary Malignant Melanoma of the Oral Cavity A Clinicopathologic and Immunohistochemical Study of 32 Cases

cases of oral mucosa malignant melanoma are analyzed clinicopathologically and immuno histochemically. The results show: there is no sex difference in the occurrence of these cases. The mean age is 41.6 years and 71.9 of the cases are above 50 years. The most common site is palate (40.6%), followed by gingival and alveolar mucosa (37.5%). The most frequent manifestation is described as a black mass. Sometimes, local lumph nodes enlarged can be touched and pigmended plaqe can be seen around the lesions. Histologically, pleomorphic tumor cells mix together and the configuration of the tumor is complex and variable. Immunohistochemically, the tumor cells are almost positive for S 100 protein and vimentin in a different degree. Varied markers are recommended in order to improve the accuracy of diagnosis.