我院2436例女性泌尿生殖道支原体感染及耐药性分析

目的:通过分析柳州市妇幼保健院2010年6月-2011年6月女性泌尿生殖道支原体感染状况及耐药性变迁,指导临床合理用药。方法:采用微量肉汤稀释法对支原体进行药物敏感性试验。结果:2436例患者检出率为40.0%(975/2436),其中解脲支原体(Uu)阳性821例(33.7%),人型支原体(Mh)阳性24例(1.0%),Uu+Mh阳性130例(5.3%)。药敏结果显示,Uu对交沙霉素、克拉霉素、强力霉素、美满霉素、阿奇霉素较敏感,Mh对美满霉素、交沙霉素、强力霉素、甲砜霉素较敏感,Uu+Mh对美满霉素、交沙霉素、强力霉素较敏感。Uu、Uu+Mh、Mh对抗生素的耐药种数不一致。结论:治疗支原体感染应选择美满霉素、交沙霉素、强力霉素等敏感性高的药物及药敏试验显示敏感的药物,喹诺酮类药耐药率高,应引起临床重视。

Analysis of Mycoplasma Infection and Drug Resistance among 2436 Female Patients in Our Hospital

OBJECTIVE: To analyze the infection and drug resistance of mycoplasma among female patients in our hospital during Jun. 2010-Jun. 2011 to provide guidance for reasonable use of drugs. METHODS: Micro-broth dilution method was used for monitoring the drug-sensitivity of mycoplasma. RESULTS: Of the total 2 436 cases, the positive rate was 40.0% (975/2 436), among which 821 cases were Ureaplasma urealyticum(Uu) positive (33.7%), 24 cases were Mycoplasma hominis(Mh) positive (1.0%), 130 cases were both Uu+Mh positive (5.3%). The sensitive drugs for Uu were josamycin, clarithromycin, deoxytetracycline, minocycline and azithromycin. The sensitive drugs for Mh were minocycline, josamycin, deoxytetracycline, thiamphenicol. Minocycline, josamycin, deoxytetracycline were sensitive to Uu+Mh. The number of drug resistant to Uu, MH, Uu+ Mh was not consistent. CONCLUSION: We should choose antibiotics such as minocycline, josamycin, deoxytetracycline to which the pathogens are sensitive in the treatment of mycoplasma infection. Mycoplasma shows a high resistance to quinolones, which should be paid high attention in clinical practice.