| 川芎嗪对创伤家兔的抗脂质过氧化作用 |
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| 引用本文： | 张连元,张之玮,董淑云,景有伶,门秀丽,张硕森.川芎嗪对创伤家兔的抗脂质过氧化作用[J].中国现代应用药学,1995(3):4-6. |
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| 作者姓名： | 张连元 张之玮 董淑云 景有伶 门秀丽 张硕森 |
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| 作者单位： | 华北煤炭医学院 |
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| 摘 要： | 在家兔创伤后，观察了动物组织损伤和机体内脂质过氧化反应情况，及川芎嗪的防治效应。结果发现，动物创伤后逐渐陷入休克状态，胞浆酶和溶酶体酶漏出。血浆和组织中脂质过氧化产物丙二醇（ＭＤＡ）含量明显增加。而应用川芎嗪防治的动物，脂质过氧化反应被有效地抑制，组织损伤表现轻微。提示，川芎嗪通过抗氧自由基损伤而对创伤动物起保护作用。
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| 关 键 词： | 川芎嗪 创伤 脂质过氧化 丙二醛 |
Antagonistic Action of Ligustrazine on Lipid Peroxidation |
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| Zhang Lian-yuan; Zhang Zhi-wei; Dong shu-yun; et al..Antagonistic Action of Ligustrazine on Lipid Peroxidation[J].The Chinese Journal of Modern Applied Pharmacy,1995(3):4-6. |
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| Authors: | Zhang Lian-yuan; Zhang Zhi-wei; Dong shu-yun; |
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| Abstract: | We observed the changes ef tissue injury and the lipidperoxidation, and theinfluence of ligustrazine on the traumatized rabbits. When rabbits was traumatized, we foundthat gradually the shock occurred and the enzymes leaved out from the cytoplasma and lysosome.In the plasma and tissue the malondialldehyde (MDA, the metabolite of lipid peroxides)content Bignifically increased. However, treatment with ligustrazine to traumatized rabbits canalleviate the changes as mentioned above. This suggested that lingustrazine can protect rabbitsfrom injury produced by oxygen free radical. |
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| Keywords: | ligustrazine trauma lipid perexide malondialdehyde |
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