首页 | 本学科首页   官方微博 | 高级检索  
     


Using previous trial results to inform hypothesis testing of new interventions
Authors:Changyu Shen  Xiaochun Li
Affiliation:1. Department of Medicine, Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;2. Department of Biostatistics, School of Medicine, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA
Abstract:
Results of industry-sponsored Phase III trials registered at clinicaltrials.gov include a rich amount of information on the efficacy of medical interventions. We propose that these results can be used to inform hypothesis testing of a new intervention through the Bayes principle. The posterior probability of positive efficacy offers an accessible interpretation of the uncertainty of efficacy and a convenient metric for global false-positive control.
Keywords:Empirical Bayes  false positive  hypothesis testing  Phase III randomized trials  posterior probability
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号