Statistical Methods for Conditional Survival Analysis |
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Authors: | Sin-Ho Jung Ho Yun Lee Shein-Chung Chow |
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Affiliation: | 1. Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA;2. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
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Abstract: | We investigate the survival distribution of the patients who have survived over a certain time period. This is called a conditional survival distribution. In this paper, we show that one-sample estimation, two-sample comparison and regression analysis of conditional survival distributions can be conducted using the regular methods for unconditional survival distributions that are provided by the standard statistical software, such as SAS and SPSS. We conduct extensive simulations to evaluate the finite sample property of these conditional survival analysis methods. We illustrate these methods with real clinical data. |
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Keywords: | Delta method Fieller method Kaplan-Meier estimator Log-rank test Martingale central limit theorem Proportional hazards model |
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