胃癌中神经内分泌细胞的临床病理学意义

 本文应用铬粒素A（CgA）、胃泌素（GAS）、生长抑素（SS）及5-羟色胺（5-HT）对120例普通型胃癌用免疫组化SP法标记其神经内分泌细胞。结果表明：四种激素抗体检测，以CgA最敏感、阳性率最高为31.7%;高分化腺癌CgA阳性率显着高于低分化和未分化癌（P<0.05）,但高分化腺癌CgA阳性病例以（+）为主，未分化癌以（++）为主；而SS.5HT的阳性率，高、低分化腺癌均高于未分化癌（P>0.05）.CgA及5-HT阳性病例淋巴结转移率高于阴性病例（P<0.05）,CgA（++）病例术后生存期明显短于CgA（+）及CgA（-）者（P<0.05）,GAS、5-HT及SS阳性与阴性病例术后生存期无显着差异。

The clinicopathological significance of neuroendocrine cells in gastric carcinoma

One hundred and twenty cases of gastric carcinomec were examined with immunohistochemical SP method for chromogranin A (CgA), gastrin (GAS), somatostain (SS) and serotonin (5-HT) follows: Among four antibodies, CgA was most specific, 31. 7% gastric carcinoma had CgA-positive cells; the positive rate of CgA in the well differentiated carcinomas was higher than that of the poorly differentiated ones and undifferentiated carcinomas (P<0. 05), CgA-positive undifferentiated carcinomas had more NE cells( ); but among different histological type,the positive rate of 5-HT and SS in undifferentiated carcinomas was lower (P>0.05). CgA and 5-HT positive cases had higher lymph node metastasis rate than the negative ones (P<0. 05). The cases with CgA-positive cells ( ) exhibited shorter survival time than those with few CgA-positive cells( ) and without CgApositive cells (P<0. 05), after having analysed the survival time, we found there was no significant difference between GAS, b-HT, SS positive and negative cases.