胃幽门螺杆菌感染与胃癌发生关系的病理学观察

 本文采用先进的PCR技术对56例胃癌、60例慢性胃炎及12例正常胃粘膜组织作了幽门螺杆菌的检测。结果，胃炎中幽门螺杆菌（HelicobacterPylori,HP）检出率93.33%,胃癌组织中检出率41.07%,正常胃粘膜中仅为16.67%.提示，胃炎的发生与HP感染明显相关，胃癌的发生与HP感染有一定的关系。从胃癌的发生部位来看，贲门癌HP感染率极低（9.52%）,而胃窦部及小弯区的癌组织中HP感染率高（68%,37.5%）,与HP易感部位在窦部及小弯处是一致的。可能是旺感染造成胃粘膜损伤、粘膜细胞活跃增生，增加了对致癌物质的敏感性。而贲门癌的发生与HP感染无关从病理分型的角度看，分化型（腺样型）的癌组织中感染率较高（55.88%）,低分化型（弥漫型）中较低（20%）,2例粘液癌中均未测到HP.本研究中分化型胃癌多位于胃窦区及小弯区，也进一步支持这一观点，另外，HP感染率在较低社会阶层人群中较高，与本文胃炎及胃癌的病员来源情况一致。

Pathologic Observation of Ralation Between the Carcinoma of Stomach and the Infection of Helicobacter Pylori

By techanique of Polymerase Chain Reaction, we analysed 56 cases of carcinoma of stomach, 60 cases of gastritis and 12 cases of normal gastric tissues. The results showed that: the infection rates of Hp were 41. 07%, 93. 3% and 16. 67%,respectively. The infection rates of carcinomas at the upper of stomach was much lower (9. 52 %)than at the middle and parts (68%, 37. 5%). The infection rates of differentiated carcinomas was 55. 8%, but poorly differentiated carcinomas was 20%.