川崎病患者易早发动脉粥样硬化

川崎病是一种急性自限性全身性血管炎,其心血管并发症,尤其是冠状动脉损害(冠状动脉扩张、冠状动脉瘤形成、冠状动脉狭窄甚至闭塞等)使其受到了临床医师,尤其是儿科临床医师的广泛关注.川崎病首次被认识至今已经40余年,随着那些最早的川崎病患者逐渐迈入中年,关于川崎病长期预后的研究引起了临床工作者的极大兴趣.虽然动脉粥样硬化性心血管疾病临床表现多出现在中老年期,但近年来其被认为是一种病变始于儿童时期,并在各种危险因素的作用下逐渐进展的疾病.越来越多的研究发现,川崎病尤其是伴有冠状动脉损害的川崎病可能是早发动脉粥样硬化的危险因素.

Patients with Kawasaki Disease Are Predisposed to Premature Atherosclerosis

Kawasaki disease is an acute self-limited systemic vasculitis.And because of its cardiovascular sequelae,especially coronary artery lesions,such as coronary artery dilatation,aneurysms,stenosis,and even occlusion,this disease is of great concern to clinicians,especially to pediatricians.It has been at least 40 years since Kawasaki disease was first reported.As the earliest patients with Kawasaki disease are now reaching middle age,there is increasing interest in the long-term prognosis of this disease.Although atherosclerosis manifests clinically in middle or older age of life,it is well-known that it begins early in life,often during childhood and develops with various risk factors.And there is increasing evidence to suggest that patients with Kawasaki disease,especially those with coronary artery lesions might be at increased risk for premature atherosclerosis.