Pseudohypoparathyroidism with diabetes mellitus and hypothyroidism |
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Authors: | Bedangshu Saikia Sunaina Arora Jacob M. Puliyel |
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Affiliation: | 1. Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi, 110 054, India
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Abstract: | We report a12-year-old child with pseudohypoparathyroidism (PHP) whose mother had pseudopseudohypoparathyroidism. The child had low serum calcium, high phosphorous and high parathormone (PTH) levels. PHP occurs due to a defect in the guanine nucleotide binding protein (G protein). She also had hypothyroidism which is known to utilize the G protein pathway. She developed T 1 diabetes mellitus (T1DM) while under follow-up. This is arguably the first time T1DM has been reported associated with PHP. |
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