Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind,placebo-controlled randomised multicenter trial [ISRCTN38327949] |
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| Authors: | Marc?GH?Besselink mailto:m.besselink@chir.azu.nl" title=" m.besselink@chir.azu.nl" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Harro?M?Timmerman,Erik?Buskens,Vincent?B?Nieuwenhuijs,Louis?MA?Akkermans,Hein?G?Gooszen,the members of the Dutch Acute Pancreatitis Study Group |
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| Affiliation: | (1) Department of Surgery, University Medical Center Utrecht, PO Box 85500, HP G04.228, 3508, GA, Utrecht, The Netherlands;(2) Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85060, 3500, AB, Utrecht, The Netherlands |
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| Abstract: | ![]()
Background Infectious complications are the major cause of death in acute pancreatitis. Small bowel bacterial overgrowth and subsequent bacterial translocation are held responsible for the vast majority of these infections. Goal of this study is to determine whether selected probiotics are capable of preventing infectious complications without the disadvantages of antibiotic prophylaxis; antibiotic resistance and fungal overgrowth. |
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