米非司酮联合甲氨蝶呤治疗异位妊娠的临床观察

目的探讨异位妊娠2种非手术治疗方法的效果。方法将异位妊娠并有非手术治疗指征的孕妇52例,随机分为2组。A组27例采用甲氨蝶呤（MTX）单次肌内注射并口服米非司酮;B组25例给予MTX（50mg/m2）单次肌内注射。监测2组血β-hCG水平和附件包块大小情况。结果 A组治愈率、血β-hCG下降≥15%、包块缩小≥30%、血β-hCG转阴时间及附件包块消失时间与B组比较,差异均有统计学意义（P〈0.05）。结论 MTX联合米非司酮用药治疗异位妊娠效果好,不良反应少,值得临床推广。

The clinical observation of mifepristone combined with methotrexate treated for ectopic pregnancy

Objective To discuss the effect of two kinds of conservative treatment of ectopic pregnancy.Methods 52 cases patients in ectopic pregnancy were randomly divided into two grous. A group（27 cases）were treated with methotrexate （MTX）a single intramuscular injection and oral administration of mifepristone;B group（28 cases）were received MTX（50mg/ m2）a single intramuscular injection. Serum β-hCG level and size of adnexal mass in two groups were monitored. Results Cure rate,blood β-hCG fall under the ≥ 15% ,mass narrowing ≥30% ,serum β-hCG clearance time and the disappearance time of adnexal mass of A group compared with that in B group,the differences were statistically significant（P 0. 05）. Conclusion MTX combined with mifepristone on ectopic pregnancy has better effect and less adverse reactions.