奥美拉唑、左氧氟沙星和阿莫西林联合治疗消化性溃疡的疗效观察

目的观察奥美拉唑、左氧氟沙星、阿莫西林联合疗法对幽门螺杆菌（Hp）的根除效果及对消化性溃疡（PU）的治疗效果。方法将115例幽门螺杆菌阳性的PU患者随机分为观察组59例和对照组56例。观察组给予奥美拉唑20mg,每天1次;左氧氟沙星500mg,每天1次;阿莫西林1000mg,每天2次。对照组给予奥美拉唑20mg,每天2次;克拉霉素500mg,每天2次;阿莫西林1000mg,每天2次。2组均饭前服用,7d为1个疗程。停药4周后复查胃镜。结果观察组和对照组溃疡治愈率和总有效率分别为86.4%、93.2%和57.1%、62.5%,2组比较差异均有统计学意义（P〈0.05）;观察组Hp根除率和减少率分别为88.1%、91.5%高于对照组的58.9%和66.1%,差异均有统计学意义（P〈0.05）。结论奥美拉唑、左氧氟沙星、阿莫西林联合治疗PU疗程短,疗效高,依从性好,药价合理,值得在基层医院推广应用。

Effect observation of omeprazole,levofloxacin and amoxicillin in treatment of peptic ulcer

Objective To observe the eradication effect of omeprazole,levofloxacin and amoxicillin triple therapy for helicobacter pylori（Hp）and the therapeutic effect for peptic ulcer（PU）.Methods 115 cases of H.pylori-positive PU patients were randomly divided into observation group（59 cases）and control group（56 cases）.The observation group gaven omeprazole 20mg,once a day;Levofloxacin 500mg,once a day;Amoxicillin 1000mg,2 times a day.While control group gave omeprazole 20mg,2 times a day;Clarithromycin 500mg,2 times a day;Amoxicillin 1000mg,2 times a day.Two groups all ate before meals,7d for a course of treatment.Withdrawal after 4 weeks,reviewed endoscopy.Results Recovery rate and efficient rate of two group respectively were 86.4%,93.2% and 57.1%,62.5%,the difference had a statistical significance（P0.05）;The eradication rate and reduce rate of hewlett-packard in observation graup were higher than that in control group（88.1% vs 58.9%,91.5% vs 66.1%）,the differences were statistical significance（P0.05）.Conclusion Omeprazole,levofloxacin and amoxicillin triple therapy for PU had merits of a short couse,high efficacy,good compliance,reasonable drug prices and cound be widely used in basic-level hospitals.