冠心病患者血清超敏C-反应蛋白测定的临床意义

目的探讨冠心病（CHD）患者血清超敏c-反应蛋白（hs．CRP）测定的临床意义。方法选择冠心病患者96例（冠心病组）及健康体检者35例（对照组），其中冠心病又分为稳定型心绞痛（SAP）亚组36例、不稳定型心绞痛（UAP）亚组28例和急性心肌梗死（AMI）亚组32例。分别对冠心病组及对照组进行血清hs．CRP水平的测定。结果冠心病患者血清hs-CRP含量明显高于正常对照组（P〈0．01）；冠心病患者各亚组间hs—CRP水平比较差异也有统计学意义（AMI〉UAP〉SAP，P均〈0．01）。CHD患者治疗后血清hs—CRP水平较治疗前明显降低（P〈0．01）。结论血清hs—CRP水平的测定，对冠心病的发生、发展、病情及预后判断有重要价值。

The clinical significance of high sensitivity C-reactive protein in patients with coronary heart disease

Objective To investigate the clinical significance of serum high sensitivity C-reactive protein （hs-CRP） detected in coronary heart disease （CHD）. Methods The serum hs-CRP in CHD patients （CHD group, n = 96）and normal control（ n = 35 ）was detected. CHD group was divided into coronary heart disease with stable angina pectoris （SAP）group（ 36 cases）, unstable angina pectoris （UAP） group （ 28 cases） and acute myocardial infarction （ AMI ） group （ 32 cases）. The serum hs-CRP of CHD group and the control group were determined. Results The levels of hs-CRP in CHD group were higher than that of the control group （P 〈 0.01 ）. There were also significantly differences among the sub groups of CHD patients （ AMI 〉 UAP 〉 SAP,P 〈 0.01 ）. Compared with before treatment, the serum level of hs-CRP in CHD patients decreased significantly af- ter treatment （P 〈 0.01 ）. Conclusion The detection of serum hs-CRP has important value for prediction of the occurrence, development, severity and prognosis of CHD.