普通型新型冠状病毒肺炎165例患者的临床和代谢特征

目的:回顾性分析普通型新型冠状病毒肺炎(COVID-19)康复患者的临床特征和血清学特点。方法:收集2020年2月23日至3月15日在湖北省武汉市雷神山医院康复出院的165例普通型COVID-19患者临床资料，按年龄分为老年和非老年组，比较2组患者的临床和血清学代谢特征。结果:165例患者中60岁以上老年占49.7%。...

Clinical and metabolic characteristics in 165 patients with common COVID-19

Objective To retrospectively analyze the clinical and serological characteristics in rehabilitated patients with common novel coronavirus pneumonia(COVID-19).Methods A total of 165 patients with common COVID-19 were enrolled in this retrospective study,in which clinical data was collected from February 23 to March 15,2020 in Leishenshan Hospital(Wuhan,China).The patients with COVID-19 were divided into elderly group and non-elderly group according to their age,and the differences in the clinical and serological metabolic characteristics between these two groups were analyzed.Results 49.7%patients were over 60 years old.The most common clinical symptoms were fever,cough,and fatigue,followed by muscle soreness.Expectoration and digestive tract symptoms were rare.Dyspnea occurred more frequently in the elderly group than in non-elderly group(47.56%vs 25.30%,P<0.01).Hypertension was the most common concomitant disease(accounting for 29.1%)followed by diabetes.Hypertension was more common in the elderly group than in non-elderly group(41.46%vs 16.86%,P<0.01),but without significant difference in diabetes between the two groups.The counts of leukocytes and lymphocytes in all patients were in the normal range,and no difference was observed between the groups.The comparison of serological indicators showed that serum creatinine in the elderly group was higher than that in the non-elderly group(P<0.01)while serum albumin,glomerular filtration rate,and serum calcium were lower in the elderly group.After serum albumin correction,the levels of albumin corrected calcium in all patients were in the normal range,without significant difference between these two groups.There was no significant difference between the two groups when the length of hospital stay was taken as the index of outcome[(34.01±10.24)vs(30.97±10.51)d,P>0.05].Conclusion Fever,cough,and fatigue are the most common clinical symptoms in patients with ordinary COVID-19.The elderly are more likely to develop dyspnea.The blood routine and metabolic characteristics in patients with common COVID-19 are normal,but serum albumin level is more likely to decrease in elderly patients with COVID-19.