| Enhancement of Antitumor Effect of Tegafur/Uracil （UFT） plus Leucovorin by Combined Treatment with Protein-Bound Polysaccharide, PSK, in Mouse Models |
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| 引用本文： | Katoh R,Ooshiro M. Enhancement of Antitumor Effect of Tegafur/Uracil （UFT） plus Leucovorin by Combined Treatment with Protein-Bound Polysaccharide, PSK, in Mouse Models[J]. Cellular & molecular immunology, 2007, 4(4): 295-299 |
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| 作者姓名： | Katoh R Ooshiro M |
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| 作者单位： | Department of Surgery, Toho University Sakura Medical Center, Sakurashi, Chiba, Japan |
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| 摘 要： | We evaluated the antitumor effect of combined therapy with tegafur/uracil （UFT） plus leucovorin （LV） （UFT/LV） and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT/LV and PSK may be expected to augment the antitumor effect.
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| 关 键 词： | 甲酰四氢叶酸 抗癌作用 皮炎菌 肺癌 免疫治疗 |
| 修稿时间： | 2007-08-122007-08-24 |
Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models |
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| Katoh Ryoji,Ooshiro Mitsuru. Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models[J]. Cellular & molecular immunology, 2007, 4(4): 295-299 |
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| Authors: | Katoh Ryoji Ooshiro Mitsuru |
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| Affiliation: | Department of Surgery, Toho University Sakura Medical Center, Sakura-shi, Chiba, Japan. ryochan@sakura.med.toho-u.ac.jp |
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| Abstract: | We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT/LV and PSK may be expected to augment the antitumor effect. |
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| Keywords: | UFT leucovorin PSK Meth A Lewis lung carcinoma colon 26 antitumor effect |
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