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| 正骨水高效液相色谱指纹图谱 | |
| 引用本文： | 范卫锋,胡琴,段婷婷,叶志文. 正骨水高效液相色谱指纹图谱[J]. 医药导报, 2020, 0(2): 212-216 |
| 作者姓名： | 范卫锋 胡琴 段婷婷 叶志文 |
| 作者单位： | 广西玉林制药集团有限责任公司;广州康臣药物研究有限公司 |
| 基金项目： | 广西重点研发计划(桂科AB16380211);珠江科技新星(201710010069);玉林市科技攻关(玉市科攻201833063) |
| 摘 要： | 目的建立正骨水高效液相色谱指纹图谱,为制剂的质量评价提供参考。方法建立正骨水高效液相色谱指纹图谱,使用中药色谱指纹图谱相似度评价系统计算相似度。结果方法学考察显示正骨水液相色谱指纹图谱精密度、重复性、稳定性均可满足指纹图谱分析的需要;指纹图谱中呈现22个共有峰,对其中3个进行了指认,19批正骨水指纹图谱相似度>0.99。结论建立的正骨水高效液相色谱指纹图谱方法能够全面反映正骨水的化学成分信息,可用于正骨水的质量评价。 |
| 关 键 词： | 正骨水 色谱法,高效液相 指纹图谱 相似度 |
HPLC Fingerprint Spectrum Analysis of Zhenggushui |
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| FAN Weifeng,HU Qin,DUAN Tingting,YE Zhiwen. HPLC Fingerprint Spectrum Analysis of Zhenggushui[J]. Herald of Medicine, 2020, 0(2): 212-216 | |
| Authors: | FAN Weifeng HU Qin DUAN Tingting YE Zhiwen |
| Affiliation: | (Guangxi Yulin Pharmaceutical Group Co,Ltd.,Yulin 537001,China;Guangzhou Consun Drug Research Ltd.,Guangzhou 510530,China) |
| Abstract: | Objective To establish an HPLC chromatographic fingerprint analysis method for the quality evaluation of Zhenggushui preparation.Methods The chromatographic fingerprint was obtained by HPLC.The similarity was calculated by using Similarity Evaluation System of Traditional Chinese Medicine Fingerprint.Results The methodology study showed that the precision,repeatability,and stability of the established HPLC method for Zhenggushui could meet the requirements for the fingerprint chromatographic analysis.There were 22 common peaks in the HPLC fingerprint spectrum,among which 3 peaks were identified.The similarity of the fingerprints from 19 batches was more than 0.99.Conclusion The established HPLC fingerprint method could provide comprehensive information of the components in Zhenggushui.It could be used for quality evaluation of the drug. |
| Keywords: | Zhenggushui Chromatography,high performance liquid Fingerprint spectrum Similarity |
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