中晚期非小细胞肺癌常见中医证型与血清前炎症因子水平相关性研究

目的:探讨中晚期非小细胞肺癌常见中医证型与血清前炎症因子水平的关系。方法:选择符合条件的中晚期非小细胞肺癌(NSCLC)患者90例及正常人30名,其中符合中医证型诊断标准的虚证、痰证、血瘀证患者各30例,所有入选受检者采用酶联免疫吸附双抗体夹心法(ELISA)检测前炎症因子白细胞介素1β(IL-1β)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)的含量。组间血清前炎症因子水平比较采用单因素方差分析。结果:NSCLC患者不同中医证型血清IL-1β、IL-6和TNF-α水平均以痰证组最高,血瘀证组次之,虚证组最低。虚证组、痰证组、血瘀证组血清IL-1β、IL-6和TNF-α均高于正常对照组,差异有统计学意义(P<0.05);虚证组IL-1β、IL-6和TNF-α及痰证组IL-1β水平低于血瘀证组,差异均有统计学意义(P<0.05);虚证组IL-1β、IL-6和TNF-α水平也低于痰证组,差异也有统计学意义(P<0.05)。结论:中晚期NSCLC虚证、痰证、血瘀证与血清前炎症因子表达程度存在一定相关性。

Correlation between common TCM syndrome types and pro-inflammatory cytokines in patients with advanced non-small cell lung cancer

Objective: To evaluate correlation between common traditional Chinese medicine syndrome types and pro-inflammatory cytokines in patients with advanced non-small cell lung cancer.Methods: 90 hospitalized patients with NSCLC were selected,who were fell into the following categories: the deficient syndrome group,the phlegm syndrome group and the syndrome of blood stasis group.The cases of each group were 30.The control group were 30.Measure serum value of IL-1β,IL-6 and TNF-α in all patients by ELISA.Variations group in between and pro-inflammatory cytokines were assessed by the statistic method ANOVA.Results: The levels of serum IL-1β,IL-6 and TNF-α in patients with advanced NSCLC were higher than that of the control group and there were significant differences between them(P<0.05).The comparison of the level of IL-1β shows significant difference between in(P<0.05).There were significant differences between the deficient syndrome group and the phlegm syndrome group or the syndrome of blood stasis group in the level of IL-6(P<0.05).Though serum value of IL-6 and TNF-α in phlegm syndrome group was higher than that in the syndrome of blood stasis group,there were no significance between them.Conclusion: The deficient syndrome,phlegm syndrome and the syndrome of blood stasis in patients with advanced NSCLC have certain correlation with the degree of the expression of the pro-inflammatory cytokines.