新疆成年人基础代谢率和颈动脉斑块相关性研究

目的了解新疆成年人基础代谢率和颈动脉斑块的相关性,提高对动脉粥样硬化的预防。方法 2007年10月至2010年3月应用四阶段整群随机抽样法,抽取新疆维吾尔族、哈萨克族、汉族18岁以上人群13 896名。进行问卷、体检和血糖、血脂检测及颈动脉斑块超声检测,采用Schofield公式计算人群基础代谢率,Logistic回归分析该人群颈动脉斑块形成的主要危险因素。结果新疆汉族、维吾尔族和哈萨克族基础代谢率分别为(1 488.8±235.2)kcal/d、(1 536.7±237.8)kcal/d和(1 454.7±220.7)kcal/d;颈动脉斑块形成组人群和无颈动脉斑块形成组人群基础代谢率分别为(1 506.71±246.80)kcal/d和(1 481.14±236.14)kcal/d(P<0.001)。Logistic回归分析显示,性别(OR:0.693,95%CI:0.554⁰.867,P=0.001),年龄(OR:1.036,95%CI:1.0280.867,P=0.001),年龄(OR:1.036,95%CI:1.028¹.044,P<0.001),基础代谢率(OR:1.982,95%CI:1.1261.044,P<0.001),基础代谢率(OR:1.982,95%CI:1.126².451,P<0.001),体重指数(OR:0.974,95%CI:0.9512.451,P<0.001),体重指数(OR:0.974,95%CI:0.951⁰.998,P=0.037),收缩压(OR:1.010,95%CI:1.0060.998,P=0.037),收缩压(OR:1.010,95%CI:1.006¹.015,P<0.001),肾小球滤过率(OR:0.995,95%CI:0.9931.015,P<0.001),肾小球滤过率(OR:0.995,95%CI:0.993⁰.998,P<0.001),甘油三酯(OR:1.092,95%CI:1.0460.998,P<0.001),甘油三酯(OR:1.092,95%CI:1.046¹.142,P<0.001)和高密度脂蛋白胆固醇(OR:0.853,95%CI:0.7421.142,P<0.001)和高密度脂蛋白胆固醇(OR:0.853,95%CI:0.742⁰.979,P=0.024)是颈动脉斑块形成的独立影响因素。结论新疆维吾尔族、哈萨克族、汉族基础代谢率和颈动脉斑块形成密切相关,且高基础代谢率为颈动脉斑块形成的独立危险因素之一。

Association of basal metabolic rate with risk of the rate of carotid artery plaque in Uygur,Kazakh and Han populations of Xinjiang

Objective To investigate association of basal metabolic rate with risk of the rate of carotid artery plaque in Uygur, Kazakh and Han populations of Xinjiang. Methods During the period of October 2007 to March 2010, the present study was performed in 13896 Han, Uygur and Kazakh adults of Xinjiang aged 18 years old and over by a four-stage random sampling method.All subjects were investigated by a standardized questionnaire, physical, biochemical examination and ultrasonography of carotid arteries. Basal metabolic rate values was calculated by Schofield equation, risk factors were analyzed by a Logistic regression model. Results Basal metabolic rate of Chinese Han, Uygur and Kazakh populations were（1 488.8±235.2） kcal/d,（1 536.7±237.8）kcal/d,（1 454.7±220.7）kcal/d, respectively. The basal metabolic rate of subjects with and without carotid artery plaque were（1 506.71± 246.80）kcal/d,（1 481.14±236.14）kcal/d（P0.001）, respectively. By the analysis of multivariate Logistic regression, gender（OR： 0.693, 95% CI： 0.554-0.867, P=0.001）, age（OR： 1.036, 95% CI： 1.028-1.044, P〈0.001）, BMR（OR： 1.982, 95% CI： 1.126-2.451, P〈0.001）, body mass index（BMI）（OR： 0.974, 95% CI： 0.951-0.998, P=0.037）, systolic pressure（SBP）（OR： 1.010, 95% CI： 1.006-1.015, P〈0.001）, glomerular filtration rate（GFR）（OR： 0.995, 95% CI： 0.993-0.998, P〈0.001）, triglyceride（TG）（OR： 1.092, 95% CI： 1.046-1.142, P〈0.001） and high-density lipoprotein cholesterol（OR： 0.853, 95% CI： 0.742-0.979, P=0.024） were independent risk factors in the occurrence of carotid artery plaque. Conclusion BMR is associated with carotid artery plaque in the populations of Xinjiang, and high basal metabolic rate is a risk factor for the rate of carotid artery plaque.