The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP) |
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| Authors: | J R Tippins H R Morris M Panico T Etienne P Bevis S Girgis I MacIntyre M Azria M Attinger |
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| Affiliation: | 1. Department of Biochemistry, Imperial College, London SW7 2AZ, U.K.;2. Department of Chemical Pathology, Royal Postgraduate Medical School, London, W12 DHS, U.K.;3. Pharmaceutical Research and Development, Sandoz Ltd., CH-4002, Basle, Switzerland. |
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| Abstract: | ![]()
Human and rat calcitonin gene-related peptides cause a dose-related contraction of guinea pig ileum, which is antagonised by an anti-histamine, mepyramine, and an anticholinergic compound, hyoscine. Both peptides also cause a positive inotropic and a positive chronotropic effect in the rat isolated auricle and these responses are antagonised by propranolol, a B adrenoceptor blocker. Further, the peptides lower plasma calcium levels in both rats and rabbits in a dose-related manner resembling calcitonin; in the rabbit, but not in the rat, the initial calcium lowering effect is succeeded by hypercalcaemia at higher doses, while in the chick, only the parathyroid hormone-like calcium-raising effect is seen. |
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| Keywords: | Reprint requests to JRT. |
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