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| 头孢曲松对表皮葡萄球菌生物膜形成的抑制作用 | |
| 引用本文： | 朱冬安,孙景勇,倪语星. 头孢曲松对表皮葡萄球菌生物膜形成的抑制作用[J]. 上海医学检验杂志, 2007, 0(6) |
| 作者姓名： | 朱冬安 孙景勇 倪语星 |
| 作者单位： | 上海市南汇区中心医院 上海201300(朱冬安)，上海交通大学医学院附属瑞金医院 上海200025(孙景勇，倪语星) |
| 摘 要： | 目的观察头孢曲松等4种抗生素抑制表皮葡萄球菌生物膜的作用,探讨抗生素防治葡萄球菌感染的作用环节。方法用半定量粘附实验筛选出形成生物膜的表皮葡萄球菌15株,观察不同浓度的药物对生物膜形成的抑制作用。结果发现头孢曲松能抑制生物膜形成,而头孢他啶、红霉素无抑制葡萄球菌生物膜的作用,万古霉素对葡萄球菌有很强的杀菌作用,但无抑制生物膜的作用。结论头孢曲松能抑制葡萄球菌生物膜形成,可利用头孢曲松抑制生物膜的作用,通过阻止粘附来阻断葡萄球菌引起的粘附相关感染,达到预防感染的目的。 |
| 关 键 词： | 表皮葡萄球菌 生物膜 头孢曲松 |
Inhibitive effect of ceftriaxone to Staphylococcus epidermidis biofilm |
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| ZHU Dong'an,SUN Jingyong,NI Yuxing.. Inhibitive effect of ceftriaxone to Staphylococcus epidermidis biofilm[J]. Shanghai Journal of Medical Laboratory Sciences, 2007, 0(6) | |
| Authors: | ZHU Dong'an SUN Jingyong NI Yuxing. |
| Affiliation: | ZHU Dong'an~1,SUN Jingyong~2,NI Yuxing~2. |
| Abstract: | Objective To observe whether ceftriaxone has inhibitive effect on the Staphylococcus epidermidis biofilm,and study the function of antibiotics in the prevention and treatment of Staphylococcus infection. Methods15 Staphylococcus epidermidis whose biofilm were positive were screened by adhesive test. The inhibitive effect of the drugs with different concentration were observed. Results Ceftriaxone could inhibit the Staphylococcus epidermidis biofilm formation while ceftazidime,erythromycin could not.Vancomycin could kill Staphylococcus strongly,but could not inhibit The biofilm formation. ConclusionsCeftriaxone is useful to prevent Staphylococcus epidermidis infection by inhibiting adhesive effect. |
| Keywords: | Staphylococcus epidermidis Biofilm Ceftriaxone |
| 本文献已被 CNKI 等数据库收录！ | |