利用知识发现工具Arrowsmith探讨天佛参口服液及其有效成分与结肠癌的相关性

目的:探讨天佛参口服液治疗结肠癌的可能机制。方法:运用非相关文献知识工具Arrowsmith软件。结果:Arrowsmith软件的初步探索结果显示天佛参口服液中的有效成分对Toll样受体(toll-like receptors,TLRs),血管内皮生长因子(vascular endothelial growth factor,VEGF),环氧合酶-2(cyclooxygenase-2,COX-2)和凋亡相关因子可能具有一定的调节作用,同时上述指标的异常表达也是造成结肠癌的重要相关遗传因素。结论:天佛参口服液在体内外均有显著抑制结肠癌的效应,其机制可能是通过下调结肠癌组织中Toll样受体4(toll-like receptor 4,TLR4)与COX-2的表达、降低组织中异常高表达的VEGF,促进促凋亡基因的表达与活力等环节发挥治疗结肠癌的作用,能为实验室进一步开展机制验证性研究提供有力的参考。

Investigate Tianfoshen Oral Liquid and Correlation Between Its Effective Components and Colorectal Cancer Using Knowledge-Discovery Tool Arrowsmith

Objective: To explore the potential mechanism of Tianfoshen oral liquid in the treatment of colorectal cancer. Method: Software of Arrowsmith based on the theory of Swan's noninterative literature-bases knowledge discovery was applied. Result: The preliminary investigation results by Arrowsmith software showed that the effective components of Tianfishen oral liquid might havecertain ability to regulate the expressions of toll-like receptors (TLRs), vascular endothelial growth factor (VEGF),cyclooxygenase-2 (COX-2), and apoptosis related factors, and the abnormal expressions of the above indicators were also the key genetic factors for colorectal cancer. Conclusion: Tianfishen oral liquid has significant effect on inhibiting colorectal cancer in vitro and in vivo, and the mechanism may be associated with down-regulating the expressions of toll-like receptor 4 (TLR4) and COX-2 in colorectal cancer tissues, reducing abnormally high expression of VEGF in tissues, and promoting expression and vitality of apoptosis genes. This can provide strong reference for the laboratory to conduct further mechanism verification studies.