动脉介入化疗加手术治疗四肢软组织肿瘤

目的　探讨动脉介入化疗加手术治疗四肢软组织肿瘤的方法与临床价值。方法　 18例肢体软组织肿瘤 ,其中 11例 ( 61% )术前影像学检查显示肿瘤与大血管及神经粘连侵犯。分别采用股动脉或肱动脉插管 ,介入化疗 2至 3周后 ,施行肿瘤广泛切除并保存患肢功能。结果　动脉介入后病理学检查 ,肿瘤均有不同程度坏死 ,体积缩小 ,周围水肿浸润带明显减少 ,肿瘤与邻近组织尤其大血管及神经间隙增宽 ,术中得以分离切除并保存患肢 ,术后随访 10～ 5 2个月 ,患肢基本功能正常。结论　对四肢软组织肿瘤 ,影像学检查大血管与神经受累但有保肢可能者 ,术前动脉介入化疗对提高切除率、降低局部复发与远处转移特别是保存患肢与功能起到积极作用。

Intraarterial Chemotherapy Plus Surgery in Patients with Extremity Soft Tissue Sarcoma

Purpose To evaluate the clinical therapeutic results of intraarterial chemotherapy plus surgery on patients with extremity soft tissue sarcoma. Methods From 1997 to 2000,18 patients with extremity soft tissue sarcoma were treated with intraarterial chemotherapy preoperatively plus surgery two weeks later.Of them,11 cases(61%) were confirmed to be adherent to the major vessels and nerves nearby by ultrasonics and CT scan.After the treatment,the limb preserving resction was achieved successfully,which does not substantially interfere with the function of the extremity. esults The size of tumor on all patients decreased gradually with a remarkable necrosis of the cells and the less invasive edge between tumor,vessel and nerve was obtained,which led to a sound limb preserving resction with their function. Conclusions The use of intraarterial chemotherapy plus surgery is an ideal approach upon extremity soft tissue sarcoma patients for limb preserving resection.