类风湿关节炎并发冠心病实验室诊断及相关性

目的 探讨相应实验室指标在类风湿关节炎 (RA) 并发冠心病 (CHD) 中的诊断价值及相关性.方法 以性别和年龄匹配设置RA并发CHD组、单纯RA组, 单纯CHD组和健康对照组各102例, 回顾性分析RA特异性指标 (ESR、RF、ACCP、IL-6) 和CHD特异性指标 (CK、CK-MB、α-HBDH、hs-TnT、Mb) 在4组中水平变化, 统计分析2组特异性指标在RA并发CHD组中的相关性.结果 4组间RA患病组 (包括单纯和并发) 关节畸形率明显高于非RA疾患组 (P<0.001) , 单纯CHD组高血压患病率及吸烟率明显高于其余3组 (P=0.016, 0.021) , 4组间BMI、TC差异无统计学意义 (P>0.05) ;RA并发CHD患者中, RA特异性指标ESR、RF、ACCP和IL-6, 以及CHD特异性指标CK、CK-MB、hs-Tn T和Mb均出现明显的升高 (P<0.05) ;ACCP与CK、CK-MB明显正相关 (P<0.05) , IL-6与CK、CK-MB、Mb明显正相关 (P<0.05) .结论 对RA患者ACCP或IL-6的检测, 可预测RA并发CHD的发生.

Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease

Objective To investigate the diagnostic value and correlation of corresponding laboratory indexes in rheumatoid arthritis (RA) complicated with coronary heart disease (CHD) . Me thods According to gender and age, patients were divided into RA concurrent CHD group, simple RA group, simple CHD group and healthy control group, with 102 cases in each group. The Level change of RA specificity index (ESR, RF, ACCP, IL-6) and CHD specificity index (CK, CK-MB, α-HBDH, hs-Tn T, Mb) in the four groups were analyzed retrospectively, and we statistically analyzed the correlation between the two groups of specific indicators in RA complicated with CHD group. Re s ults The rate of joint deformity in RA sick group (including simple and concurrent) was significantly higher than that in non-RA group (P =0.000) , the hypertension prevalence and smoking rate in simple CHD group were significantly higher than the other three groups (P=0.016, 0.021) , there was no significant difference in BMI and TC between the four groups (P>0.05) In patients with RA complicated with CHD, the RA specificity index of ESR, RF, ACCP and IL-6, and CKD specificity index of CK, CK-MB, hs-Tn T and Mb were significantly increased (P <0.05) . ACCP was positively correlated with CK and CK-MB (P <0.05) , IL-6 was positively correlated with CK, CK-MB and Mb (P <0.05) . Conclus ion The detection of ACCP or IL-6 in RA patients can predict the incidence of RA complicated with CHD.