地塞米松预防肺癌骨转移患者姑息放疗导致疼痛加重的临床研究

  目的   探讨地塞米松在有效缓解肺癌骨转移患者姑息放疗导致的疼痛加重及其安全性。  方法   选取山东大学附属千佛山医院2011年1月至2016年4月收治的103例肺癌骨转移患者随机分为地塞米松(观察组)和安慰剂(对照组)治疗，其中观察组51例，对照组52例，分别于放疗后给予地塞米松(5 mg，iv)/安慰剂(生理盐水1 mL，iv)治疗，比较两组患者放疗后疼痛情况。  结果  观察组的51例患者中13例(25%)发生疼痛加重；对照组的52例患者中20例(38%)发生疼痛加重(P = 0.03)。  结论  地塞米松可减少肺癌骨转移放疗引起的疼痛加重，该结论仍需进一步的研究证实。 

Dexamethasone in the prophylaxis of radiation-induced pain deterioration after palliative radiotherapy for bone metastases from lung cancer

  Objective  To evaluate the efficacy and safety of dexamethasone in alleviating radiation-induced pain deterioration following palliative radiotherapy in patients with bone metastases from lung cancer.  Methods   A total of 103 patients with bone metastases from lung cancer were randomly assigned into the observation group (n=51) and the control group (n=52). Dexamethasone (5 mg, iv) or placebo (saline, 1 mL) was administered after radiation. The incidence of pain deterionation in the two groups was compared.  Results  Of the 51 cases in observation group, 13 (25%) had pain deterioration. While 20 patients (38%) experienced aggravated pain in the control group (P = 0.03).  Conclusion  Dexamethasone alleviated pain deterioration in patients with bone metastases from lung cancer following palliative radiotherapy, which needs to be confirmed by further studies.