| 昆明地区中小学学生的5-HT转运体蛋白基因(SLC6A4)与儿童品行障碍的关联性 |
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| 作者姓名： | 林雁 张京晶 黄高贵 张翼宇 芮溧 姚树祥 |
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| 作者单位： | 1. 昆明医科大学第一附属医院头颈外科 |
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| 基金项目： | 基金: 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB113); 云南省教育厅科研基金资助项目(2016ZZX098,2016ZZX091); |
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| 摘 要： | 目的 研究中国昆明地区汉族人群5-HT转运体蛋白基因(SLC6A4)多态性与儿童品行障碍之间是否存在关联性,综合探索中国儿童品行障碍人群的重要危险因素和高危人群,为预防提供理论依据.方法 入选品行障碍患儿88名,使用外显品行障碍行为量表(BAS)进行测量;并应用聚合酶链反应方法检测受试者的5-HT转运体蛋白基因(SLC6A4)基因多态性.结果 对各基因型及基因型频数分布进行比较,有品行障碍的受试者与无品行障碍受试者的结果,差异无统计学意义(P>0.05);按性别进行分组后,进行等位基因频率比较:在男性受试者中,有品行障碍者与无品行障碍者比较,差异有统计学意义(P<0.05);而在女性受试者中,结果比较,差异无统计学意义(P>0.05).结论 昆明地区中小学生5-HT转运体蛋白基因(SLC6A4)多态性可能与儿童品行障碍之间有一定的关联.
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| 关 键 词： | 品行障碍 基因多态性 转运体蛋白基因 5-羟色胺 |
| 收稿时间： | 2016-12-07 |
Correlation of 5-HT Transporter Protein Gene (SLC6A4) Polymorphism and Conduct Disorder in Children |
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| Abstract: | Objective To investigate the correlation of 5-HT transporter protein gene(SLC6A4)polymorphism and conduct disorder in children in primary and middle school in Kunming area. Methods Eighty-eight students with conduct disorder were studied. The technique of polytnerase Chain Reaction was used to study the SLC6A4 gene in conduct disorder. Results There was no statistically significant difference between conduct disorder and non-conduct disorder group in genotypes and allele frequencies. There was statistically significant difference in male group(P <0.05) but no in female group(P >0.05).Conclusions The SLC6A4 gene polymorphism may be correlated with conduct disorder in children. |
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