糖尿病视网膜血管病变中未折叠蛋白反应:蛋白质折叠的意义和治疗潜力

血管生成是由多因素共同参与调节，涉及正常的胚胎发育以及出生后的一种复杂的病理过程，如癌症、心血管疾病和糖尿病。而糖尿病视网膜病变（diabetic retinopathy，DR）则是眼科疾病中常见的糖尿病微血管病变，其中视网膜和脉络膜异常的血管生长是导致视力丧失的主要原因，它与血管变性、缺血、视网膜组织血管重构互为因果并动态关联。了解视网膜新生血管的机制，研发具有创新性的治疗方案是今后努力的方向。越来越多的证据表明，未折叠蛋白反应（unfold protein response，UPR）在调节血管生成方面扮演着非常重要的角色。本文总结了目前在视网膜内质网中的UPR相关研究以及UPR在DR新生血管形成和血管重构的信号，强调这些应激反应途径在预防和治疗导致视力缺陷和失明的DR中的潜在意义。

Unfolded protein response in diabetic retinopathy:significance and therapeutic potential of protein folding

Angiogenesis is a complex pathological process that is composed of many factors involved in the regulation，which relates to the normal embryonic development and postnatal，such as cancer，cardiovascular disease，and diabetes.However，diabetic retinopathy is one of the most common diabetic microangiopathy in eye diseases，meanwhile，retinal neovascularization which is causally and dynamically associated with vasodegeneration，ischemia，and vascular remodeling in retinal tissues are the main causes of visual loss.Understanding the mechanisms of retinal neovascularization as well as researching of innovative treatment program has become the direction of our efforts.Accumulating evidence suggests a vital role for the unfolded protein response （UPR） in regulation of angiogenesis.So this article summarizes current research in the context of UPR and UPR signaling in diabetic retinopathy angiogenesis and vascular remodeling，high lighting potential implications of targeting these stress response pathways in the prevention and treatment of retinal vascular diseases that result in visual deficits and blindness.