2型糖尿病患者合并周围神经病变的危险因素分析

目的 调查某三甲医院住院2型糖尿病(T2DM)患者的相关临床资料并分析其合并糖尿病周围神经病变(DPN)的危险因素。 方法 采用回顾性调查与分析方法,收集广东药科大学附属第一医院2016年1-12月住院T2DM患者240例,按是否合并DPN,分为DPN组和非DPN组(NDPN组)。分别对2组的人口学资料(性别、年龄、病程、吸烟史、饮酒史、婚姻状况、户口类型、付费方式)、体格检查资料(BMI、SBP、DBP)、相关生化资料(FBG、2 h PG、HbA1c、FC-P、2 h C-P、TC、TG、LDL-C、HDL-C、FFA、BUN、UA、Scr)及是否合并并发症(HTN、CHD、DR、DN、PVD)等进行比较,运用多因素Logistic回归的方法分析T2DM患者合并DPN的危险因素。 结果 DPN组的年龄、病程、合并CHD、DR及FBG、FFA高于NDPN组(P<0.05);DPN组的2 h C-P、BUN、UA低于NDPN组(均P<0.05)。多因素Logistic回归分析显示,年龄(OR=1.558,95% CI:1.051~2.310)、病程(OR=1.758,95% CI:1.078~2.866)、FBG(OR=1.091,95%CI:1.006~1.183)、2 h C-P(OR=0.643,95% CI:0.352~0.843)及合并DR(OR=2.649,95% CI:1.422~4.934)与DPN的发生密切相关。 结论 年龄、病程、FBG及合并DR是T2DM患者发生DPN的危险因素,2h C-P是其保护因素。 

Risk factors analysis of diabetic peripheral neuropathy in patients with type 2 diabetes

Objective To investigate the relevant clinical data in a hospital and analyze the risk factors of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods By adopting the method of retrospective investigation and analysis, 240 hospitalized patients from January, 2016 to December, 2016 were collected in Guangdong pharmaceutical university. According to the merger of DPN, the patients were divided into DPN group and NDPN group. The data were compared between two groups, including demographic data (gender, age, course of the disease, smoking history, drinking history, marital status, account type, payment method), physical examination data(BMI, SBP, DBP), the relevant biochemical information(FBG, 2 h PG, HbA1c, FC-P, 2 h C-P, TC, TG, LDL-C, HDL-C, FFA, BUN, UA, Scr) and whether merger of complications(HTN, CHD, DR, DN, PVD) via multivariable Logistic regression method to analyze the risk factors of T2DM patients with DPN. Results The age, course, CHD, DR, FBG, FFA in DPN group were significantly higher than those in NDPN group (P<0.05); 2 h C-P, BUN, UA were significantly lower than those in NDPN group (P<0.05). The logistic regression analysis showed that age(OR=1.558, 95% CI:1.051-2.310), course of disease(OR=1.758, 95% CI:1.078-2.866), FBG(OR=1.091, 95% CI:1.006-1.183), 2 h C-P(OR=0.643, 95% CI:0.352-0.843) and DR (OR=2.649, 95% CI:1.422-4.934) were closely correlated with DPN occurrence. Conclusion Age, course of disease, FBG and DR are the high risk factors of DPN occurrence in patients with T2DM, and 2 h C-P is the protective factor of DPN.