Caveolin-1在腮腺多形性腺瘤及瘤旁组织中的表达及临床意义 |
| |
引用本文: | 张松,田向永,袁孝伟,柯少瑞,孙志艳,莫赛军. Caveolin-1在腮腺多形性腺瘤及瘤旁组织中的表达及临床意义[J]. 中国肿瘤临床, 2014, 41(7): 449-452. DOI: 10.3969/j.issn.1000-8179.20131149 |
| |
作者姓名: | 张松 田向永 袁孝伟 柯少瑞 孙志艳 莫赛军 |
| |
作者单位: | ①.郑州大学第一附属医院(郑州市450052) |
| |
基金项目: | 国家自然科学基金项目81101686河南省教育厅科学技术研究重点基金项目12A310008 |
| |
摘 要: | ![]() 目的 探讨窖蛋白-1(Caveolin-1,Cav-1)在腮腺多形性腺瘤(pleomorphic adenoma,PA)中的表达及临床意义。 方法 采用免疫组织化学法检测了9例正常腮腺、33例原发性PA距离瘤体中心(0 cm)及瘤旁组织中(分别距瘤体中心0.5、1.0、1.5和2.0 cm)Cav-1的表达,并进行统计学分析。 结果 Cav-1在所有正常腮腺样本(100%)均有表达,其主要在导管系统细胞质和细胞膜中表达;除6例距瘤体中心0.5 cm和1例距瘤体中心1.0 cm的样本外,其余瘤旁样本均有Cav-1表达,其表达模式基本上与正常腮腺类似;在PA中,有10例样本(30.30%)表达Cav-1,且在细胞核中显著表达。Cav-1在多形性腺瘤肿瘤组织中的表达最低,并随着与瘤体中心距离的远近,其表达量逐渐升高。Cav-1的表达在瘤体与瘤旁组织间均存在明显差异(P < 0.05),但瘤旁组织1.0、1.5和2.0 cm间Cav-1表达无显著性差异(P>0.05)。 结论 在腮腺多形性腺瘤发生过程中,Cav-1中表达下调并出现了从细胞质、细胞膜到细胞核的转位现象。上述结果表明Cav-1在多形性腺瘤的发生发展中可能起着重要作用,其表达水平的变化可作为判定手术安全边缘的科学依据之一。
|
关 键 词: | Caveolin-1 多形性腺瘤 腮腺 手术切缘 |
收稿时间: | 2013-07-16 |
Expression and clinical significances of caveolin-1 in pleomorphic adenoma and paraneoplastic tissues of parotid gland |
| |
Affiliation: | ①.The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052②.Department of Basic Oncology, Basic Medical College of Zhengzhou University, Zhengzhou 450001③.Department of Radiotherapy, Zhengzhou People's Hospital, Zhengzhou 450053④.The Army Orthopaedic Trauma Center, No. 153 Central Hospital of The Chinese People's Liberation Army, Zhengzhou 450001, China |
| |
Abstract: | ![]() Objective This study was conducted to explore the expression and clinical significance of caveolin-1 (Cav-1) in pleomorphic adenoma and paraneoplastic tissues of the parotid gland. Methods Immunohistochemistry was used to detect Cav-1 expression in normal parotid glands, pleomorphic adenoma (0 cm), and paraneoplastic tissues (0.5, 1.0, 1.5, and 2.0 cm from the pleomorphic adenoma). Results Cav-1 was expressed in all normal parotid glands and was mainly expressed in the cytoplasm and plasma membrane of duct systems. Except for six samples 0.5 cm away and one sample 1.0 cm away from the pleomorphic adenoma, Cav-1 was expressed in other adjacent normal tissues, and the expression pattern of Cav-1 was similar to that in normal tissues. In pleomorphic adenoma, Cav-1 only existed in seven samples (accounting for 30.30%) and was prominently expressed in the nucleus. The expression level of Cav-1 was lowest in pleomorphic adenoma and progressively increased with increasing distance from the tumor. A difference in Cav-1 expression was detected between pleomorphic adenoma (0 cm) and paraneoplastic tissues (0.5, 1.0, 1.5, and 2.0 cm from the tumor, P < 0.05). However, no statistical significance existed between paraneoplastic tissues at 1.0, 1.5, and 2.0 cm from the tumor (P> 0.05). Conclusion During the development of pleomorphic adenoma, the expression level of Cav-1 progressively decreased, and translocation of Cav-1 expression from cytoplasm and plasma membrane to nucleus occurred. Cav-1 may have an important role in the progress of pleomorphic adenoma, and the variation in the expression level of Cav-1 may be used as a scientific evidence to determine the safe surgical margin of pleomorphic adenoma. |
| |
Keywords: | |
|
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载免费的PDF全文 |
|