稳定期慢性阻塞性肺疾病的抗生素治疗进展

慢性阻塞性肺疾病(COPD)是一种呼吸系统常见的慢性疾病,炎症反应在其发生、发展过程中是导致一系列病理生理改变的重要机制.根据病程可分为稳定期和急性加重期,目前的研究表明对于易出现急性加重的患者,一年内长期使用阿奇霉素或红霉素可减少急性加重风险(A级证据),至于长期使用抗生素的安全性和有效性仍待更多的研究.现针对稳定期COPD的抗生素治疗作一综述,探讨不同给药方式及抗生素种类对COPD患者的益处、不良反应以及耐药性的影响,旨在为临床工作提供参考.

Antibiotic treatment progress of stable chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease(COPD)is a common chronic disease in respiratory system.Inflammatory response is an important mechanism leading to a series of pathophysiological changes in the course of development.The natural course can be divided into stable and acute exacerbation phase.Present study suggests that using long-term azithromycin and erythromycin within a year can reduce the risk of exacerbations for patients with frequently acute exacerbation(evidence grade A).As to the effectiveness and safety of long-term use of antibiotics needs for more research.This paper summarizes the antibiotic treatment for stable COPD to investigate the influence of benefits,adverse reactions and drug resistance due to the different ways of drug delivery and kinds of antibiotics in patients with COPD,and aims to provide reference for clinical work.