| 微小RNA在三阴性乳腺癌中的研究进展 |
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| 引用本文： | 汪成. 微小RNA在三阴性乳腺癌中的研究进展[J]. 中华内分泌外科杂志, 2020, 14(2): 166-169 |
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| 作者姓名： | 汪成 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院黄浦分院乳腺外科 200011 |
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| 基金项目： | 上海市医学重点专科建设项目基金(ZK2015A07)。 |
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| 摘 要： | 三阴性乳腺癌(triple-negative breast cancer,TNBC)是指免疫组织指标ER、PR、HER2三者均为阴性的一种乳腺癌分子亚型,也是一种高度异质性的疾病.TNBC与其他乳腺癌分子亚型相比,生物学行为上表现侵袭性强、易复发和内脏转移,易产生耐药性,预后不良.miRNA是一种很有前景的生物标志物和...
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| 关 键 词： | 三阴性乳腺癌 微小RNA |
Research progress of microRNA in triple negative breast cancer |
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| Wang Cheng. Research progress of microRNA in triple negative breast cancer[J]. Chinese Journal of Endocrine Surgery, 2020, 14(2): 166-169 |
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| Authors: | Wang Cheng |
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| Affiliation: | (Department of Breast Surgery,Huangpu Branch,Shanghai Ninth People’s Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China) |
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| Abstract: | Triple negative breast cancer(TNBC),regarded as a highly heterogeneous disease,is a kind of molecular subtype of breast cancer with negative in estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor-2(HER2).Compared with other subtypes of breast cancer,TNBC is high aggressive in biological behavior,prone to recurrence and visceral metastasis,drug resistance and poor prognosis.MicroRNA(miRNA)is a promising biomarker and forecasting tool,which could be used for diagnosis and treatment of breast cancer at various stage.In this study,we reviewed the research progress of miRNA in TNBC in the aspects of high aggression,potential treated targets,screening of prognosis biomarkers,drug resistance,prediction of pCR in neoadjuvant therapy,and association with BRCA1/2 mutation,etc.to offer reference for early screening and diagnosis,clinical treatment and prognosis judgment of TNBC. |
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| Keywords: | Triple negative breast cancer MicroRNA(miRNA) |
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