AIF-1基因多态性、体质指数与口腔癌发病风险的关联研究

目的 探讨同种异体移植炎症因子-1（allograft inflammatory factor-1，AIF-1）基因多态性、体质指数（body mass index，BMI）及其交互作用与口腔癌易感性的关系。方法 采用病例对照研究，收集2010年9月~2016年12月经病理确诊的新发口腔癌患者300例及同期该医院体检人群445例。应用TaqMan探针技术检测AIF-1基因的单核苷酸多态性（single nucleotide polymorphisms，SNPs）。采用非条件Logistic回归分析计算比值比（odd ratios，OR）值及95%可信区间（confidence intervals，CI），分析AIF-1基因多态性、BMI及其交互作用与口腔癌易感性的关系。结果 GG基因型在共显性模型（OR=0.522，95%CI:0.319～0.855）和隐性模型（OR=0.573，95%CI:0.368～0.893）中均可降低口腔癌的发病风险。进一步的分层分析表明GG基因型在男性、BMI≥24.0 kg/m2、吸烟、非饮酒亚组中同样可降低口腔癌的发病风险。此外，结果还显示BMI<18.5 kg/m2可增大口腔癌的发病风险，而BMI≥24.0 kg/m2则是口腔癌的保护因素，并且AIF-1基因与BMI之间存在相乘交互作用。结论 AIF-1基因rs2857595基因SNPs和BMI≥24.0 kg/m2能降低口腔癌的发病风险，且rs2857595与BMI存在相乘交互作用。

Association of single nucleotide polymorphism of AIF-1 gene and body mass index with susceptibility to oral cancer

Objective To explore the association of allograft inflammatory factor-1 (AIF-1) gene polymorphisms, body mass index (BMI) and their interactions with susceptibility to oral cancer. Methods A case-control study including 300 patients with pathologically confirmed oral cancer from September 2010 to December 2016 and 445 cancer-free controls was performed. The genotypes were determined by TaqMan genotyping assay. Unconditional Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) to assess the association of AIF-1 gene polymorphisms, BMI and their interactions with susceptibility to oral cancer. Results In the co-dominant genetic model(OR=0.522, 95% CI:0.319-0.855) and the recessive genetic model(OR=0.573, 95% CI:0.368-0.893), subjects carrying GG genotype of rs2857595 had significantly reduced risk of oral cancer, respectively. Moreover, GG genotype was a clear protective factor in male, individuals with BMI ≥ 24.0 kg/m2, and smoking and non-drinking subgroups. By contrast, BMI<18.5 kg/m2 was a risk factor of oral cancer, and BMI ≥ 24.0 kg/m2 reduced the risk of oral cancer. In addition, statistical analysis suggested an interaction between AIF-1 rs2857595 polymorphism and BMI. Conclusions This study suggests that AIF-1 rs2857595 polymorphism and BMI ≥ 24.0 kg/m2 may be protective factors for oral cancer. And there may be a multiplicative interaction between AIF-1 and BMI.