IL-27在非小细胞肺癌患者外周血中的表达

目的探讨IL-27在非小细胞肺癌(Non-small-cell lung cancer,NSCLC)患者外周血中的表达。方法选取2012年12月²014年3月在我院就诊的NSCLC患者50例。根据NSCLC分期,分为NSCLCⅠ期组、NSCLCⅡ期组、NSCLCⅢ期组、NSCLCⅣ期组;同时选取8名健康志愿者作为对照组。采用酶联免疫吸附法检测各组研究对象外周血细胞因子IL-27、IL-12、IL-10的表达水平。结果各组外周血IL-27、IL-12、IL-10等炎症因子浓度进行比较,均存在统计学差异(p<0.05);其中NSCLCⅢ期和NSCLCⅣ期的IL-27和IL-12浓度分别较其他组明显降低(p<0.05),NSCLCⅢ期和NSCLCⅣ期的IL-10浓度分别较其他组明显升高(p<0.05)。外周血IL-27、IL-12浓度与NSCLC分期呈负相关(p<0.001),外周血IL-10浓度与NSCLC分期呈正相关(p<0.001)。结论 IL-27可能参与了NSCLC相关炎症反应,IL-27可能是NSCLC治疗的潜在药物。

THE EXPRESSION OF IL-27 IN PERIPHERAL BLOOD OF PATIENTS WITH NON-SMALLCELL LUNG CANCER

Objective To investigate the expression of IL-27 in peripheral blood of patients with non-small-cell lung cancer（NSCLC）. Methods According to the tumorous grading and staging,50 patients with NSCLC admitted in our hospital were divided into NSCLC I group,NSCLC II group,NSCLC III group and NSCLC IV group,while 8 healthy volunteers as the control group. The expression level of IL-27,IL-12 and IL-10 were determined by Enzyme-linked immunosorbent assay.Results There was significant difference between the groups in the concentration of IL-27,IL-12 and IL-10 in peripheral blood of patients with NSCLC（p 〈 0. 05）. In NSCLC III and NSCLC IV groups,the concentrations of IL-27 and IL-12 were lower（p 〈0. 05） and the concentration of IL-10 was higher（p 〈 0. 05） than those of other groups. In peripheral blood,the NSCLC grading and staging was negatively correlated to the concentrations of IL-27 and IL-12 but positively to the concentration of IL-10（p 〈 0. 001）. Conclusion IL-27 may participate in the inflammation related to NSCLC,therefore,it may be a potential agent for NSCLC treatment.