宫颈阴道分泌液中IL-8、铜、锌含量与胎膜早破关系的研究

目的：对胎膜早破（PROM）孕妇宫颈阴道分泌液中基质金属白介素-8（IL-8）、微量元素（铜、锌）的含量与PROM的关系进行探讨。方法：选择足月初产胎膜早破孕妇40例（PROM组）和正常足月初产孕妇未破膜者40例（对照组），分别用双抗体夹心ELISA法和溶出电极法测定阴道分泌液中IL-8和铜、锌的含量。结果：PROM组阴道分泌液中IL-8水平平均为657．20±83．33μg／ml，明显高于对照组421．54±22．35pg／ml，差异有显著性（P〈0．01）；PROM阴道分泌液中铜、锌的含量分别为2．18±1．57μg／L，0．45±0．17μg／L，均明显低于对照组3．67±2．07μg／L，0．72±0．36μg／L，差异有显著性（P〈0．01）。结论：PROM组孕妇阴道分泌液中IL-8含量明显升高，而铜、锌含量明显降低，对胎膜早破的早期诊断有一定帮助。

In the cervix of the uterus vagina secretion IL--8, the copper, the zinc content and the fetal membrane break the price record the department early the research

Objective：To fetal membrane early broken （PROM） pregnant woman cervix of the uterus vagina secretion in matrix metal Bai Jiesu - 8（IL-8）, trace element （copper, zinc） the content and the PROM relations carry on the discussion. Method： Chooses the full--term first birth fetal membrane early broken pregnant woman 40 examples （the PROM group） and the normal full -- term first birth pregnant woman not broken membrane 40 examples （control group）, uses the double immune body to contain fill- ing separately the ELISA law and dissolves in the electrode law determination vagina secretion IL--8 and copper, the zinc content. Results：In the PROM group vagina secretion the IL--8 level is 657. 20±83.33μg/ml equally, is higher than control group 421. 54± 22. 35μg/ml obviously, the difference has the significance （P《0.01）. In the PROM vagina secretion copper, the zinc content re- spectively be 2. 18±1.57 μg/L, 0. 45±0.17 μg/L, obviously is lower than the control group 3. 67±2.07 μg/L, 0. 72±0.36 μg/ L, the difference has the significance （P〈0.01）. Conclusions： In the PROM group pregnant woman vagina secretion the IL--8 content elevates obviously, but the copper, the zinc content reduce obviously, has certain help early to the fetal membrane broken early diagnosis.