硝普钠与西地兰治疗急性左心衰竭的有效性及安全性比较

目的：研究硝普钠与西地兰治疗急性左心衰竭患者中的有效性和安全性。方法选取医院心内科住院急性左心衰竭病患者56例，随机分为硝普钠组与西地兰组各28例。2组在常规治疗基础上分别予硝普钠及西地兰治疗，比较2组患者血压、心率、症状缓解时间、不良反应等。结果2组患者血压和心率情况均得到良好控制，硝普钠组控制情况优于西地兰组，差异有统计学意义（P ﹤0.05）。2种药物对急性左心衰竭治疗均具良好效果（有效率﹥90％）；硝普钠组心力衰竭症状缓解所需时间更短，起效更快，差异有统计学意义（P ﹤0.05）。2组治疗后均未出现心律失常、血压下降过快、休克等不良反应。结论硝普钠与西地兰治疗急性左心衰竭均有明显效果，安全性较高；硝普钠对比西地兰在治疗效果、起效时间上具有优势。

Efficacy and safety of sodium nitroprusside in the treatment of patients with acute left heart failure compared with cedilanid

Objective To study the efficacy and safety of sodium nitroprusside and cedilanid in the treatment of pa-tients with acute left heart failure. Methods 56 cases of patients diagnosed acute left heart failure in the Department of Cardi-ology in our hospital were selected and randomly divided into sodium nitroprusside group and cedilanid group,each of 28 ca-ses. Bases on the routine treatment,the 2 groups were treated with sodium nitroprusside and cedilanid respectively. The blood pressure,heart rate,time of symptom relief,adverse reaction and etc were compared. Results Blood pressure and heart rate of 2 groups were well controlled,but the sodium nitroprusside group was better than that of cedilanid group,the difference was sta-tistically significant（P ﹤ 0. 05）. Both drugs were effective in the patients with acute left heart failure（effective rate ﹥ 90% ）. The heart failure symptoms time was shorter in sodium nitroprusside group compared with cedilanid group,the difference was statistically significant（P ﹤ 0. 05）. Both groups had no adverse reaction such as arrhythmia,Blood pressure drop too fast, shock,etc. Conclusion Sodium nitroprusside and cedilanid were in effect in the treatment of acute left heart failure,with high security,but the sodium nitroprusside has advantages in treatment effect and onset time.