The blocking effects of omega-conotoxin on Ca current in bovine chromaffin cells |
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| Authors: | M Hans P Illes K Takeda |
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| Affiliation: | Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacologie Cellulaire et Moléculaire-CNRS, Illkirch, France. |
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| Abstract: | ![]()
The effects of omega-conotoxin (omega-CgTX) on voltage-sensitive Ca currents (ICa) were studied in cultured bovine adrenal chromaffin cells. A maximal block of ICa of 40-50% was obtained with omega-CgTX in the microM range, and was independent of the holding potential. The onset of block was both concentration- and time-dependent. In bovine chromaffin cells, Ca channels, both sensitive and insensitive to omega-CgTX, appear to be present. |
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