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| Density of Helioobacterpylo／Ymay affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers | |
| 引用本文： | Lai YC,Wang TH,Huang SH,Yang SS,Wu CH,Chen TK,Lee CL. Density of Helioobacterpylo／Ymay affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers[J]. World journal of gastroenterology : WJG, 2003, 9(7): 1537-1540. DOI: 10.3748/wjg.v9.i7.1537 |
| 作者姓名： | Lai YC Wang TH Huang SH Yang SS Wu CH Chen TK Lee CL |
| 作者单位： | Yung-Chih Lai,Sien-Sing Yang,Chi-Hwa Wu,Tzen-Kwan Chen,Chia-Long Lee(Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan, China);Teh-Hong Wang(Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, China);Shih-Hung Huang(Department of Pathology, Cathay General Hospital, Taipei, Taiwan, China) |
| 摘 要： | |
| 关 键 词： | 十二指肠溃疡 幽门螺旋杆菌 兰索那唑 克拉霉素 阿莫西林 疗效 |
| 收稿时间： | 2003-03-12 |
Density of Helicobacter pylori may affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers |
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| Lai Yung-Chih,Wang Teh-Hong,Huang Shih-Hung,Yang Sien-Sing,Wu Chi-Hwa,Chen Tzen-Kwan,Lee Chia-Long. Density of Helicobacter pylori may affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers[J]. World journal of gastroenterology : WJG, 2003, 9(7): 1537-1540. DOI: 10.3748/wjg.v9.i7.1537 | |
| Authors: | Lai Yung-Chih Wang Teh-Hong Huang Shih-Hung Yang Sien-Sing Wu Chi-Hwa Chen Tzen-Kwan Lee Chia-Long |
| Affiliation: | 1. Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan, China 2. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, China 3. Department of Pathology, Cathay General Hospital, Taipei, Taiwan, China |
| Abstract: | AIM: To evaluate the association of pre-treatment Helicobacter pylori (H. pylori) density with bacterial eradication and ulcer healing rates in patients with active duodenal ulcer. METHODS: One hundred and four consecutive duodenal ulcer outpatients with H. pylori infection ascertained by gastric histopathology and (13)C-urea breath test (UBT) were enrolled in this study. H. pylori density was graded histologically according to the Sydney system (normal, mild, moderate, and marked). In each patient, lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) were used for 1 week, then 30 mg lansoprazole once daily was continued for an additional 3 weeks. Follow-up endoscopy was performed at 4 weeks after completion of the therapy, and UBT was done at 4 and 8 weeks after completion of the therapy. RESULTS: The H. pylori eradication rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 69.7 %/85.2 %; and the ulcer healing rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 63.6 %/77.8 % (intention-to-treat/per protocol analysis) in the mild, moderate, and marked H. pylori density groups, respectively. The association of pretreatment H. pylori density with the eradication rate and ulcer healing rate was both statistically significant (P=0.013/0.006 and 0.002/<0.001, respectively; using results of intention-to-treat/per protocol analysis). CONCLUSION: Intragastric bacterial load may affect both the outcome of eradication treatment and ulcer healing in patients with active duodenal ulcer disease. |
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