| 新型顺铂纳米微球的制备及性质研究 |
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| 引用本文： | 龚丽萍,李茹恬,刘宝瑞. 新型顺铂纳米微球的制备及性质研究[J]. 现代肿瘤医学, 2010, 18(1) |
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| 作者姓名： | 龚丽萍 李茹恬 刘宝瑞 |
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| 作者单位： | 1. 东南大学医院,江苏,南京,210018
2. 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏,南京,210008 |
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| 基金项目： | 国家自然科学基金，江苏省研究生创新计划项目 |
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| 摘 要： | 目的:采用自行合成的高分子载体,制备负载顺铂的纳米微球,全面考察其性质.方法:通过开环聚合法,制备单甲氧基聚乙二醇-聚己内酯(mPEG-PCL)两嵌段聚合物以及末端带有羟基的PCL作为载体, 采用优化的w/o/w双乳化扩散/挥发法,制备负载顺铂的纳米微球.考察载体的结构、分子量、纳米微球的形态、粒径分布、稳定性、生物相容性等性质.结果:通过开环聚合法合成mPEG-PCL两嵌段聚合物以及末端带有羟基的PCL,测定分子量和设计分子量相近.通过双乳剂法制备的空白粒子平均粒径为326.9±5.4nm,载药粒子在冻干前后的粒径分别为339.1±4.9及370.3±2.5nm.粒子呈规整的球形,在水溶液中稳定.顺铂的载药效率为77.4%,载药量为4.72%.体外释放实验显示,载药粒子具有缓释特征,在6h、24h、48h分别释放53%、75%、93%.载体在高浓度时对细胞生长无抑制作用,毒性低.结论:研究表明这种新型载药系统具有良好的应用价值.
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| 关 键 词： | 顺铂 纳米粒子 双乳剂法 药物输送体系 抗肿瘤 |
Novel nanoparticles of cisplatin:Preparation and study of properties |
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| GONG Li-ping,LI Ru-tian,LIU Bao-rui. Novel nanoparticles of cisplatin:Preparation and study of properties[J]. Journal of Modern Oncology, 2010, 18(1) |
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| Authors: | GONG Li-ping LI Ru-tian LIU Bao-rui |
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| Affiliation: | GONG Li-ping1,LI Ru-tian2,LIU Bao-rui2 1Southeast University Hospital,Nanjing 210008,China,2The Comprehensive Cancer Center of Drum-Tower Hospital,Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University,China. |
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| Abstract: | Objective:to prepare cisplatin-loaded nanoparticles with bi-block copolymer mPEG-PCL and PCL,and evaluate their properties.Methods:mPEG-PCL and HO-PCL were synthesized by ring-opening polymerization method and the nanoparticles were prepared by developed w/o/w double emulsion method.The structure and molecular weight of the polymers,the morphology of the nanoparticles,as well as their stability and biocompatibility were studied.Results:mPEG-PCL and PCL were synthesized with desired molecular weight.The diam... |
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| Keywords: | cisplatin nanoparticles w/o/w double-emulsion method drug-delivery system antitumor |
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