| 颈动脉粥样硬化斑块内纤溶酶原激活抑制物-1表达的研究 |
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| 引用本文： | 李华,蒲传强,门保忠,周定标.颈动脉粥样硬化斑块内纤溶酶原激活抑制物-1表达的研究[J].卒中与神经疾病,2005,12(6):329-333. |
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| 作者姓名： | 李华 蒲传强 门保忠 周定标 |
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| 作者单位： | 1. 100853,北京,中国人民解放军总医院神经内科
2. 100853,北京,中国人民解放军总医院神经外科 |
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| 摘 要： | 目的观察颈动脉粥样硬化(AS)斑块内纤溶酶原激活抑制物-1(PAI-1)的mRNA和抗原的表达情况.方法分别应用原位杂交和免疫组织化学测定颈AS斑块内PAI-1mRNA和抗原表达.结果相对于正常动脉内膜,颈AS病变内膜PAI-1阳性细胞数明显增多(P＜0.05),其中颈AS严重病变肩区阳性细胞数最多,且以单核-巨噬细胞为主.结论PAI-1与颈AS发生有关.
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| 关 键 词： | 颈动脉 动脉粥样硬化 纤溶酶原激活抑制物-1 |
| 文章编号： | 1007-0478（2005）06-0329-05 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2005-06-132005-07-22 |
Study on expression of PAI-1 in the carotid atherosclerotic plaques |
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| Li Hua, Pu Chuanqiang, Men Baozhong,et al..Study on expression of PAI-1 in the carotid atherosclerotic plaques[J].Stroke and Nervous Diseases,2005,12(6):329-333. |
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| Authors: | Li Hua Pu Chuanqiang Men Baozhong |
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| Institution: | Department of Neurology, The General Hospital of PLA, Beijing 100853 |
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| Abstract: | Objective To observe the mRNA and antigen expression of PAI-1 in the carotid atherosclerotic plaques. Methods Antigen and mRNA of PAI-1 was measured by immunocytochemistry and hybridization in situ respectively. Results PAI-1-positive cells in the intimas of the Carotid AS plaques increased more than those in the intimas of the normal arterial walls. There were many PAI-1-positive cells in the shoulder areas of the advanced lesions. The positive cells in the shoulder areas were mainly monocytes and macrophages. Conclusions ICAM-1 is associated with the carotid atherosclerosis. |
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| Keywords: | Carotid artery Atherosclerosis PAI-1 |
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