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Hemolytic Anemia in a Patient with Subacute Bacterial Endocarditis by Cardiobacterium hominis
Authors:Motohiro Shingu  Naoto Ishimaru  Jun Ohnishi  Shimpei Mizuki  Yohei Kanzawa  Kei Kawano  Takahiro Nakajima  Nobuya Sano  Saori Kinami
Affiliation:1.Department of General Internal Medicine, Akashi Medical Center, Japan; 2.Department of Pathology, Akashi Medical Center, Japan
Abstract:
Hemolytic anemia is a rarely occurring manifestation of native valve infective endocarditis. We herein report an afebrile patient with hemolytic anemia caused by Cardiobacterium hominis endocarditis. A 60-year-old Japanese man had a history of aortic root replacement and the gradual onset of general fatigue. He had hemolytic anemia. Blood cultures detected C. hominis. A transthoracic echocardiogram showed aortic valve vegetation and periannular abscess with perforation of the non-coronary cusp. Intravascular hemolysis recovered after antimicrobial therapy, surgical removal of the vegetation and abscess, and aortic valve replacement. Subacute endocarditis should be considered if patients develop hemolytic anemia with signs of chronic inflammation without a fever.
Keywords:Cardiobacterium hominis   intravascular hemolysis   infective endocarditis
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