精神分裂症患者血清41种微量元素定量检测及分析

目的探讨血清中多种微量元素含量改变与精神分裂症的关系。方法应用高灵敏度的电感耦合等离子体质谱仪与原子发射光谱仪定量检测了119例精神分裂症患者血清中41种微量元素含量,并与126例正常人做对照,结合患者不同性别、不同年龄段及不同病程进行了分组比较。结果患者组硼、铝、锶、锂、镍、锑、铬、锰、钾、钠、磷11种元素血清含量显著升高;钛、锗、砷、钴、镉、锡、铋、钍、铀、铊、镧、铈、镨、钕、钆、铜、硫、锌18种元素血清中含量显著降低。精神分裂症患者组与性别差异相关的元素有磷、砷、铷、钛、锑;与不同年龄段相关的元素有硼、铜,不同病程比较血清元素含量无明显相关性。结论多种微量元素广泛参与了精神分裂症的发病及病理过程,多种元素的丰缺或多元素的综合作用可能是造成患者中枢神经系统功能紊乱的元素基础。

Quantitative detection and analysis of 41 kinds of trace elements in serum of patients with schizophrenia

Objective To discuss the relationship of changes between trace elements and schizophrenia.Methods Forty-one kinds of trace elements in serum of 119 patients with schizophrenia were detected using inductively coupled plasma mass spectrometry(ICP-MS) and atomic emission spectrometry and compared with 126 healthy controls,combined with different gender,age and clinical courses.Results Eleven kinds of elements(boron,aluminum,strontium,lithium,nickel,antimony,chromium,manganese,potassium,sodium and phosphorus) in serum of those with schizophrenia were significantly increased,while 18 kinds of elements(titanium,germanium,arsenic,cobalt,cadmium,tin,bismuth,thorium,uranium,thallium,La,cerium,PR,ND,gadolinium,copper,sulfur,and zinc) in serum were significantly decreased.There were significant differences in phosphorous,arsenic,rubidium,titanium and antimony,in terms of a connection to gender,and in boron and copper in connection with age.There was no significant correlation of element content in different course of disease.Conclusion Multiple trace elements widely involved in schizophrenia pathogenesis and pathological processes,and the abundance or deficiency of elements may be the underlying factors of central nervous system dysfunction of patients.