Detection of chromogranin in argyrophil cells of endometrial carcinoma |
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| Authors: | G Ueda T Nishino J Saito Y Abe H Shimizu O Tanizawa |
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| Affiliation: | 1. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China;2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;1. Swiss Tropical and Public Health Institute, Basel, Switzerland;2. University of Basel, Basel, Switzerland;3. ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain;4. Pompeu Fabra University, Barcelona, Spain;5. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, Madrid, Spain;6. Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, 46020 València, Spain;7. University of Granada, Center for Biomedical Research (CIBM), & Biosanitary Research Institute of Granada (ibs.GRANADA), Spain;8. Institute of Non-ionizing Radiation (INIS), Ljubljana 1000, Slovenia;9. BIODONOSTIA Health Research Institute, Dr. Begiristain Pasealekua, San Sebastian, Spain;10. University of the Basque Country (UPV/EHU), Preventative Medicine and Public Health Department, Faculty of Medicine, Leioa, Spain;11. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands;12. Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA;13. Danish National Birth Cohort, Statens Serum Institute, Copenhagen, Denmark;14. Danish Epidemiology Science Centre, Department of Public Health, Aarhus University, Aarhus, Denmark;15. ib-salut, Area de Salut de Menorca, Menorca, Spain;p. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;q. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre–Sophia Children''s Hospital, Rotterdam, the Netherlands;1. Princess Margaret Cancer Centre, University Health Network; Ontario Institute for Cancer Research; and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada;2. Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN, USA;3. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;4. Department of Pathology, Weill Cornell Medicine, New York, NY, USA;5. Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA;6. Department of Haematology and Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa;7. Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA |
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| Abstract: | ![]()
Normal and neoplastic endometrial tissues were examined immunohistochemically for chromogranin which was shown to be a specific marker for neuroendocrine cells. All 20 normal endometriums and 20 endometrial carcinomas without argyrophilia were chromogranin negative. Endometrial carcinomas with argyrophilia tested were composed of three groups; 10 with type I argyrophil cells, 20 with type II argyrophil cells, and 10 with both type I and II argyrophil cells. Type I argyrophil cells of 20 endometrial carcinomas were all chromogranin positive. Chromogranin immunoreactivity was also intimately correlated with the Grimelius reactivity in type II argyrophil cells of 19 endometrial carcinomas, 13 with only type II argyrophil cells and 6 with mixed type of argyrophil cells. Chromogranin was absent in type II argyrophil cells of 11 endometrial carcinomas, 7 with type II argyrophil cells and 4 with mixed type of argyrophil cells. Chromogranin negativity was related to the disappearance of argyrophilia after diastase digestion in 5 of these 11 tumors, and also partly to mucinous substances in the remaining 6 tumors. In conclusion, the results obtained suggest that some of type II argyrophil cells are neuroendocrine in nature as well as type I argyrophil cells. |
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