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| 1,25（OH）2维生素D3诱导小鼠混合培养细胞白细胞介素1αmRNA … | |
| 引用本文： | 张丁 Loren.,J. 1,25（OH）2维生素D3诱导小鼠混合培养细胞白细胞介素1αmRNA …[J]. 中华口腔医学杂志, 1998, 33(6): 375-377 |
| 作者姓名： | 张丁 Loren. J |
| 摘 要： | 本研究旨在探讨破骨细胞形成过程中１，２５（ＯＨ）２维生素Ｄ３「１，２５（ＯＨ）２Ｄ３」和白细胞介素１α两种生物因子间的相互作用关系，以期进一步了解正畸牙齿移动过程中牙周组织改建的生物学机理。 |
| 关 键 词： | 破骨细胞 白细胞介素1 维生素D3 mRNA 正畸学 |
1,25(OH)2 vitamin D3 induces IL-1 alpha mRNA expression from osteoblastic-like and bone marrow co-culture cells] |
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| D Zhang,J Lorenzo. 1,25(OH)2 vitamin D3 induces IL-1 alpha mRNA expression from osteoblastic-like and bone marrow co-culture cells][J]. Chinese journal of stomatology, 1998, 33(6): 375-377 | |
| Authors: | D Zhang J Lorenzo |
| Affiliation: | School of Stomatology, Beijing Medical University, Beijing 100081. |
| Abstract: | OBJECTIVE: The purpose of this research is to investigate the relationship between 1,25(OH)2 Vitamin D3[1,25(OH)2D3] and Interleukin-1 (IL-1) in regulating osteoclast formation. The result may enrich our knowledge about biological mechanisms of periodontal tissue remodeling during orthodontic tooth movement. METHODS: We found IL-1 alpha mRNA expression in bone marrow and osteoblastic cell co-cultures by semi-quantitative RT-PCR. RESULTS: 1,25(OH)2D3 increased IL-1 alpha mRNA expression from this co-culture cells in a dose dependent manner, and the expression reached its peak in day 2 and decreased thereafter. CONCLUSION: These results demonstrate that IL-1 alpha involves in osteoclast formation induced by 1,25(OH)2D3. And we propose IL-1 alpha may stimulate the proliferation of osteoclast progenitor during the first 4 days of total 6 days culture period. |
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