| 乳腺癌骨转移研究进展 |
| |
| 引用本文： | 闫敏,崔树德,江泽飞.乳腺癌骨转移研究进展[J].国际肿瘤学杂志,2009,36(8). |
| |
| 作者姓名： | 闫敏 崔树德 江泽飞 |
| |
| 作者单位： | 河南省肿瘤医院乳腺科,郑州,450008 |
| |
| 摘 要： | 骨是乳腺癌最常见的转移部位之一,乳腺癌骨转移以溶骨性病变为主,也有少部分为成骨性病变,目前的研究表明趋化因子、整合素、血管生成以及骨微环境与癌细胞的相互作用等在乳腺癌骨转移的过程中起了重要作用.
|
| 关 键 词： | 乳腺肿瘤 肿瘤转移 骨肿瘤 |
Research advancement on breast cancer metastasis to bone |
| |
| Abstract: | Breast carcinoma frequently metastasizes to bone tisuue, and approximately 70% of patients with breast cancer have bone metastasis, which generally are osteolytic lesions. What is the basis for their prefer-ential growth within the bone microenvironment? Bidirectional interaction between tumor cells and normal cells that make up bone result in a selective advantage for tumor growth and can lead to bone destruction or new bone matrix deposition. This review will discuss our current understanding of the molecular components and mecha-nisms that are responsible for those interactions. |
| |
| Keywords: | Breast neplasms Neoplasm metastasis Bone neoplasms |
| 本文献已被 万方数据 等数据库收录！ |
|
