| 安非他酮治疗卒中后抑郁的临床疗效及其对脑源性神经营养因子的影响 |
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| 引用本文： | 徐倩,安宏伟,韩真贤,赵希武,孙大伟,李淑华,王锐成. 安非他酮治疗卒中后抑郁的临床疗效及其对脑源性神经营养因子的影响[J]. 中国健康心理学杂志, 2017, 25(6). DOI: 10.13342/j.cnki.cjhp.2017.06.010 |
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| 作者姓名： | 徐倩 安宏伟 韩真贤 赵希武 孙大伟 李淑华 王锐成 |
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| 作者单位： | 1. 中国.黑龙江省大庆市第三医院 163712;2. 大庆油田总医院 |
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| 基金项目： | 黑龙江省大庆市指导性科技计划项目 |
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| 摘 要： | 目的:探讨安非他酮治疗卒中后抑郁的临床疗效及其对脑源性神经营养因子(BDNF)的影响。方法:对60例卒中后抑郁的患者采用安非他酮治疗,疗程8周,并在治疗前及治疗后2、4、6、8周评定药物疗效和副反应以及BDNF的水平。结果:治疗后2、4、6、8周末HAMD总分均较治疗前明显降低,重复测量方差分析结果(F=1501.920,P=0.000),血清BDNF水平治疗前与治疗后对比即较治疗前明显升高,重复测量方差分析结果(F=1558.802,P=0.000)。结论:安非他酮治疗卒中后抑郁临床疗效较好,且抑郁程度与BDNF水平负相关。
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| 关 键 词： | 安非他酮 卒中后抑郁 脑源性神经营养因子 副反应量表 |
Effect of Bupropion on Depression after Post-stroke and Brain Deriven Neurotrophic Factor |
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| Abstract: | Objective:To investigate the effect of bupropion on post-stroke depression and the brain deriven neu-rotrophic factor(BDNF).Methods:A total of 60 patients with post-stroke depression were treated with bupropion. The period of study was 8 weeks.HAMD,TESS and BDNF were used to assess the efficacy and side effects before and 2 weeks,6 weeks and 8 weeks after the treatment.Results:Total scores of HAMD and HAMA decreased signifi-cantly at the end of the 2nd,4th,6th and 8th week(F =1501.920,P <0.001).BDNF scores from 2 weeks to 8 weeks increased dramatically as compared to pretreatment(F =1558.802,P <0.001).Conclusion:Bupropion in treating pa-tients with post-stroke depression has good anti-depressant.The degree of depression is negatively related to the level of BDNF. |
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| Keywords: | Bupropion Post-stroke depression BDNF TESS |
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