益寿饮颗粒对衰老动物模型免疫功能的影响

目的探讨益寿饮颗粒剂对衰老动物模型免疫功能的影响。方法模型大、小鼠各60只，按20只分组，分为生理盐水对照组、益寿饮小剂量组和益寿饮大剂量组。各组连续灌胃30d，停药后小鼠摘取眼球取肝素抗凝静脉血，大鼠自尾静脉取血，测IL-1α，IL-2，IL-6，RBC—C3bRR，RBC-ICR以及外周血T淋巴细胞亚群。结果大、小剂量组与对照组比较，IL-1α，IL-2，IL-6水平明显升高，RBC—C3bRR结合率明显升高，RBC—ICR结合率明显下降，CD3^＋，CD4^＋淋巴细胞的比值明显升高，CD8^＋淋巴细胞的比值明显降低，各项指标均具有统计学意义。结论益寿饮颗粒提高衰老动物模型T淋巴细胞增殖和产生白介素-1（IL—1）、白介素-2（IL-2）、白介素-6（IL-6）的能力，增强红细胞膜RBC—C3bRR活性及粘附IC的能力，影响外周血T淋巴细胞亚群分类的水平，影响外周血T淋巴细胞亚群的数量、活性及亚群细胞之间的比例，调节T细胞的免疫功能，改善机体免疫调节功能。

Effect of Immunological Function by Yishouyin Granula in Aging Animal Models

Objective To investgate the effect of immunological function by Yishouyin granula in aging animal models. Methods Sixty Wistar rats were divided into 3 groups：low dosage group, high dosage group and control group. After 30 day ＇s ingastrio - infusion, the level of serum IL - 1 α, IL - 2, IL - 6, RBC - C3 bRR, RBC - ICR and T lymmphcyte sub groups were determined by enzymyradiography. Results Compared to control group, the level of serum IL - 1 α, IL - 2, IL - 6 were higher significantly, the combinated rate of RBC - C3bRR was eleveted, the combinated rate of RBC - ICR was decreased significantly;the level of CD3 ^＋ CD4 ^＋ was eleveted,while CD8^＋ was decreased significantly. Conclusion It was drawn from the experiment that Yishouyin granula could better the immunological function by eleveting the level of serum IL - 1 α, IL - 2, IL - 6 and strongthening the active function of RBC - Cs bRR as the same as adherion of immunological complex.