Sensitivity and specificity of a self-administered questionnaire for familial screening of adult-onset dystonia. |
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Authors: | Maria Stella Aniello Davide Martino Gianluca Masi Paolo Livrea Giovanni Defazio |
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Affiliation: | Department of Neurological and Psychiatric Sciences, University of Bari, Italy. |
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Abstract: | We developed a self-administered questionnaire for screening the most common adult-onset dystonias. It was tested in 90 first-degree relatives of 22 adult-onset dystonia patients, yielding 79% sensitivity and 94% specificity. Simulation of a case-finding procedure based on serial application of the questionnaire and clinical examination of both subjects screening positive and subjects screening negative who had < 8 years of schooling increased sensitivity to 95% and specificity to 100%. This questionnaire may be an important screening resource for familial aggregation studies to be used in the context of a complex case-finding procedure. |
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Keywords: | adult dystonia questionnaire family history epidemiology diagnosis |
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