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| 药物累积法研究热痹清片的药物动力学 | |
| 引用本文： | 刘雅敏,张黎莉,娄玉钤,李振国. 药物累积法研究热痹清片的药物动力学[J]. 辽宁中医杂志, 2006, 33(9): 1171-1172 |
| 作者姓名： | 刘雅敏 张黎莉 娄玉钤 李振国 |
| 作者单位： | 1. 河南中医学院,河南,郑州,450008 2. 河南省食品药品检验所,河南,郑州,450008 3. 河南风湿病医院,河南,郑州,450045 |
| 摘 要： | 目的:研究热痹清片在小鼠体内的药物动力学过程。方法:采用药物累积法,以小鼠急性死亡率为指标,测定小鼠灌胃给药后不同时间的药物体存量,估算表观药物动力学参数。结果:药物毒性效应呈一级动力学过程,符合二房室模型。其动力学参数为:分布速率常数α和消除速率常数β分别为2.2272h-1及0.2031h-1;其分布半衰期t1/2α和消除半衰期t1/2β分别为0.3112h和3.4121h。结论:热痹清片小鼠灌胃给药易于吸收,毒性较大,分布快,但消除较慢。其表观药物动力学参数可为临床合理用药作参考。 |
| 关 键 词： | 热痹清片 制马钱子 药物累积法 药物动力学 |
| 文章编号： | 1000-1719(2006)09-1171-02 |
| 收稿时间： | 2006-07-21 |
| 修稿时间： | 2006-07-21 |
Studies on the Toxicity and Effect Kinesics of Rebiqing Tablet |
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| Liu Yamin,Zhang Lili,Lou Yuqian,Li Zhenguo. Studies on the Toxicity and Effect Kinesics of Rebiqing Tablet[J]. Liaoning Journal of Traditional Chinese Medicine, 2006, 33(9): 1171-1172 | |
| Authors: | Liu Yamin Zhang Lili Lou Yuqian Li Zhenguo |
| Affiliation: | 1. Henan Traditional Chinese Medical College , Zhengzhou 450008,Henan, China; 2. Henan Institute for Drug Control, Zhengzhou 450008 ,Henan, China ;3 Henan Province Hospital of Rheumatic Diseases, Zhengzhou 450045 ,Henan, China |
| Abstract: | Objective: Research on pharmacodynamics of the Chinese medicine Rebiqing tablet in mouse intimate.Methods: Adopting drug accumulation,and using the mouse acute mortality rate as indicators to measure the different times after intragastric administration of the mouse and estimate apparent pharmacokinetics parameters.Results: The effect of drug-toxicity shows the first order processes,and it consistents with the two compartment model.Its kinesics parameters as follow:α were 2.2272 h~(-1) and β were(0.2031) h~(-1);t_(1/2α)is 0.3112h and relimination half life t_(1/2 β)is(3.4121h).Conclusion: The Rebiqing tablet is easy to absorb.It distributes fast and eliminates slow.Its causing death dosage and pharmacokinetic parameters can provide reference for clinical rational administration. |
| Keywords: | Rebiqing tablet Strychnos alkaloids drug accumulation pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |