Synthesis and pharmacology of new camptothecin drugs |
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| Authors: | Driver Russell W Yang Li-Xi |
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| Affiliation: | Radiology Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA 94118, USA. |
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| Abstract: | Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog. |
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