| 阿霉素-PLGA微球体外释药特性的研究 |
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| 引用本文： | 罗斌华,丁洁琼,阎志飞,丁红. 阿霉素-PLGA微球体外释药特性的研究[J]. 解放军药学学报, 2013, 0(4): 340-342 |
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| 作者姓名： | 罗斌华 丁洁琼 阎志飞 丁红 |
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| 作者单位： | [1]湖北科技学院药学院,湖北咸宁437100 [2]山西医科大学药学院,山西太原030001 |
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| 基金项目： | 校级青年基金,No.KY10061 |
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| 摘 要： | 目的阿霉素-PLGA微球体外释药特性的研究。方法以透析法考察阿霉素-PLGA微球的体外释药行为,采用紫外分光光度计在波长233 nm处测定阿霉素-PLGA微球的体外释药量。结果在0.1～20μg.ml-1浓度范围内,阿霉素浓度与吸光度之间呈良好的线性关系,药物的释放符合Higuchi方程。结论该方法简便、快速、准确,可作为阿霉素-PLGA微球体外释药的测定方法。
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| 关 键 词： | 微球 体外释药 |
Release Characteristics of Adriamycin-PLGA Microspheres in vitro |
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| LUO Bing-hua①,DING Jie-qiong①,YAN Zhi-fei②,DING Hong. Release Characteristics of Adriamycin-PLGA Microspheres in vitro[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2013, 0(4): 340-342 |
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| Authors: | LUO Bing-hua① DING Jie-qiong① YAN Zhi-fei② DING Hong |
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| Affiliation: | ② ①School of Pharmaceutics,Hubei University of Science and Engineering,Xianning 437100,China; ②School of Pharmacy,Shanxi Medical University,Taiyuan 030001,China |
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| Abstract: | Objective To study the release characteristics of lung targeting adriamycin-PLGA microspheres in vitro.Methods Dialysis method was used to test the property of microsphere release in vitro,and the ultraviolet spectrophotometry was used to examine the release of adriamycin-PLGA microspheres at 233 nm.Results The linear range was 0.1-20 μg · ml-1 for adriamycin-PLGA microspheres.The release in vitro was characterized by Higuchi equation.Conclusion A simple,quick and accurate method for determining the release rate in vitro of adriamucin-PLGA microsoheres is established. |
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| Keywords: | microspheres release in vitro |
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